Evidence map›Paper›PMID 40333260›Full record

ArticleVaccines2025

Respiratory Syncytial Virus (RSV) Hospitalization Seasonal Patterns and Economic Burden in the US: Implications for Further Optimizing the Use of RSV Preventives.

Amy W Law, Jay Lin, Jennifer Judy, Sarah J Pugh, Alejandro Cane

Abstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amy W LawGlobal Access & Value, Pfizer, Inc., New York, NY 10001, USA.ORCID 0009-0009-8030-3733
Jay LinOutcomes Research, Novosys Health LLC, Miami, FL 33145, USA.
Jennifer JudyGlobal Respiratory Vaccines, Real World Evidence, Pfizer, Inc., New York, NY 10001, USA.ORCID 0000-0002-2246-9745
Sarah J PughVaccines, US Medical and Scientific Affairs, Pfizer, Inc., Collegeville, PA 19426, USA.ORCID 0000-0003-4347-2561
Alejandro CaneVaccines, US Medical and Scientific Affairs, Pfizer, Inc., Collegeville, PA 19426, USA.

Funding

Pfizer (United States) NA
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe CDC has recommended immunizations to protect infants during the respiratory syncytial virus (RSV) season, which varies annually and geographically. Seasonal differences in RSV hospitalizations among infants are not well studied.

methodsThis retrospective cohort study identified infants < 12 months old hospitalized with RSV from the PINC AI Healthcare Database during the 2018-2023 surveillance years (1 July-30 June). Monthly RSV hospitalizations were stratified by U.S. census division and age group (<3, 3-5, 6-8, 9-11 months). Patient characteristics, healthcare resource utilization (HCRU), and cost were compared between typical in-season months (October-March) and typical off-season months (April-September) for RSV hospitalizations.

resultsAmong 20,531 hospitalizations for RSV (mean age: 4.1 months, 56.4% male), 22% (

conclusionsThere is an unmet need among the 1 in 5 infants with off-season RSV hospitalizations, which are associated with higher HCRU and costs. Current recommendations on RSV preventives offer limited protection for infants exposed to RSV outside the typical season.

Indexed as

hospitalizationinfantoff-seasonrespiratory syncytial virusseasonal variation

Identifiers

PMID40333260
PMCPMC12030787

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.