Evidence map›Paper›PMID 40333240›Full record

ArticleVaccines2025

A Phase 3 Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Adult-Specific Pneumococcal Vaccine, Compared with PPSV23, in Adults ≥50 Years of Age (STRIDE-10).

Veronika Jotterand, Vinita Jagannath, Andrea Accini Diaz, Juan Diego Velez, Arna Letica, Silvia Narejos Perez, Rebecca Clark, Yoseph Caraco, Olaf Degen, Kyung-Hwa Park and 9 more

Registry-linked trialAbstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05569954 (A Phase 3, Randomized, Double-blind, Active Comparator-controlled Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Pneumococcal Vaccine-naïve Adults 50 Years of Age or Older), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05569954 phase3completednot on this map

A Phase 3, Randomized, Double-blind, Active Comparator-controlled Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Pneumococcal Vaccine-naïve Adults 50 Years of Age or Older

TypeinterventionalSponsorMerck Sharp & Dohme LLCRan2022 to 2025Enrolled1,484ConditionsPneumococcal DiseaseArmsV116, PPSV23
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Veronika JotterandMSD, 6005 Lucerne, Switzerland.
Vinita JagannathMSD (UK) Limited, 120 Moorgate, London EC2M 6UR, UK.ORCID 0000-0001-6785-8181
Andrea Accini DiazIPS Centro Cientifico Asistencial S.A.S, Barranquilla 080020, Colombia.
Juan Diego VelezFundacion Valle del Lili, Cali 760032, Colombia.
Arna LeticaOptimal Clinical Trials, Auckland 1010, New Zealand.
Silvia Narejos PerezCAP Centelles, 08540 Barcelona, Spain.ORCID 0000-0002-7720-9289
Rebecca ClarkLayton Medical Centre, Flyde Coast Clinical Research, 200 Kingscote Drive, Blackpool FY3 7EN, UK.
Yoseph CaracoDivision of Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University, Jerusalem 91120, Israel.
Olaf DegenUniversity Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Kyung-Hwa ParkChonnam National University Medical School, Department of Infectious Diseases, Gwangju 61469, Republic of Korea.
Serhat ÜnalDepartment of Infectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, 06100 Ankara, Turkey.ORCID 0000-0003-1184-4711
Frederick WittkeMSD, The Circle 66, Zürich Airport, 8058 Zürich, Switzerland.ORCID 0000-0003-3945-7684
Kimberly HurtadoMerck & Co., Inc., Rahway, NJ 07065, USA.
Clay ChurchillMerck & Co., Inc., Rahway, NJ 07065, USA.
Ying ZhangMerck & Co., Inc., Rahway, NJ 07065, USA.
Doreen FernslerMerck & Co., Inc., Rahway, NJ 07065, USA.
Jianing LiMerck & Co., Inc., Rahway, NJ 07065, USA.
Ulrike K BuchwaldMerck & Co., Inc., Rahway, NJ 07065, USA.ORCID 0000-0002-6671-0115
Heather PlattMerck & Co., Inc., Rahway, NJ 07065, USA.

Funding

Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA N/A
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adultinvasive pneumococcal diseaseopsonophagocytic activitypneumococcal conjugate vaccineserotype

Identifiers

PMID40333240
PMCPMC12031205

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.