Evidence map›Paper›PMID 40333233›Full record

ArticleVaccines2025

Incidence of Confirmed Influenza and Pneumococcal Infections and Vaccine Uptake Among Virologically Suppressed People Living with HIV.

Edith Wolder Ejlersen, Josefine Amalie Loft, Marco Gelpi, Safura-Luise Heidari, Omid Rezahosseini, Johan Runge Poulsen, Dina Leth Møller, Zitta Barrella Harboe, Thomas Benfield, Susanne Dam Nielsen and 1 more

Abstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Edith Wolder EjlersenDepartment of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0009-0004-9684-1812
Josefine Amalie LoftDepartment of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0002-8779-803X
Marco GelpiDepartment of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
Safura-Luise HeidariDepartment of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0009-0005-4706-6220
Omid RezahosseiniDepartment of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North Zealand, 3400 Hillerød, Denmark.ORCID 0000-0003-2198-1904
Johan Runge PoulsenDepartment of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
Dina Leth MøllerDepartment of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0002-3909-0643
Zitta Barrella HarboeDepartment of Pulmonary and Infectious Diseases, Copenhagen University Hospital, North Zealand, 3400 Hillerød, Denmark.ORCID 0000-0001-5552-0095
Thomas BenfieldDepartment of Infectious Diseases, Copenhagen University Hospital-Amager and Hvidovre, 2650 Hvidovre, Denmark.ORCID 0000-0003-0698-9385
Susanne Dam NielsenDepartment of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.ORCID 0000-0001-6391-7455
Andreas Dehlbæk KnudsenDepartment of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.

Funding

Augustinus Foundation N/ALundbeck Foundation N/ANovo Nordisk Foundation 12495Rigshospitalet Research Counsil E-23719-25
6 · The paper itself

Abstract

BACKGROUND/

objectivesInfluenza and

methodsWe included 1031 virologically suppressed PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) study. Data on infections and vaccinations between 2015 and 2020 were collected from nationwide registries. Incidence rates with 95% confidence intervals (CIs) of confirmed influenza and pneumococcal infections and vaccine uptake were calculated, and predictors of vaccine uptake were explored using logistic regression.

resultsThe IR of influenza showed variation from year to year and ranged between 0 (95% CI: 0.0, 7.6) and 18.0 (95% CI: 8.2, 34.1) per 1000 person-years at risk with an overall IR of 8.4 per 1000 person-years at risk (95% CI: 5.4, 12.3). The overall IR of pneumococcal infections was 5.5 per 1000 person-years at risk (95% CI: 3.9, 7.5). Among PLWH, 53.2% were influenza-vaccinated at least once, 72.3% and 22.6% of PLWH were vaccinated at least twice and in all six seasons, respectively, while 31% had at least one pneumococcal vaccine. Previous pneumonia or bronchitis, higher body mass index, use of drugs to treat heart conditions, and longer time with HIV were independently associated with vaccine uptake.

conclusionsWe found high incidences of confirmed influenza and pneumococcal infections in virologically suppressed PLWH, but vaccine uptake was below recommendations, highlighting the need for improved vaccination counseling.

Indexed as

influenzapeople living with HIVpneumococcal infectionsS. pneumoniaevaccine uptake

Identifiers

PMID40333233
PMCPMC12030955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.