ArticleCell reports2025
EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8
Abstract read
In one paragraph
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Renaissance of antiviral CD8Nature reviews. Immunology · 2026Review
- Genetic and transcriptomic signatures of host control in HIV-1 infection.Retrovirology · 2026Article
- Integrating network toxicology with multi-omics approaches to elucidate molecular targets and pathway mechanisms in BPA-induced hepatocellular carcinoma.Molecular diversity · 2026Article
- Recapitulating the qualities of HIV-specific CD8 + T cells from spontaneous controllers.Current opinion in HIV and AIDS · 2026Review
- Article
- Endothelial-specific Ezh2 deficiency exacerbates blood-brain barrier dysfunction and neuroinflammation in sepsis-associated encephalopathy.Journal of neuroinflammation · 2026Article
- HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses.bioRxiv : the preprint server for biology · 2026Article
- NK Cells Engineered with a Chimeric Antigen Receptor Delay HIV Rebound and Reshape HIV Reservoir Composition.bioRxiv : the preprint server for biology · 2026Article
- Persistent immune dysfunction during suppressive antiretroviral therapy: implications for analytical treatment interruption trials for chronic HIV infections in sub-Saharan Africa.Frontiers in immunology · 2026Review
- HIV Nef amplifies mechanical heterogeneity to promote immune evasion.bioRxiv : the preprint server for biology · 2025Article
- Resist to persist: resistance of the HIV reservoir to immune-mediated clearance.Current opinion in HIV and AIDS · 2025Review
- A Participant-Derived Xenograft Mouse Model to Decode Autologous Mechanisms of HIV Control and Evaluate Immunotherapies.Bio-protocol · 2025Article
- Immunomodulatory biomaterials in HIV-1 infection prevention, control and treatment.Frontiers in immunology · 2025Review
- Epigenetic regulation of CD8Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Andrea GramaticaInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Itzayana G MillerInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Adam R WardInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Farzana KhanInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Tyler J KemmerInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Jared WeilerInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Tan Thinh HuynhInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Paul ZumboDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA.
Andrew P KurlandDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029 USA.
Louise LeyreInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Yanqin RenInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Thais KlevornInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Dennis C CopertinoInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Uchenna ChukwukereInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Callie LevingerDepartment of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20052, USA.
Thomas R DillingInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Noemi LindenInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Nathan L BoardInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Emma Falling IversenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Sandra TerryInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Talia M MotaInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Seden BedirDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Kiera L ClaytonDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Alberto BosqueDepartment of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20052, USA.
Lynsay MacLaren EhuiWhitman Walker Health, Washington, DC 20005, USA.
Colin KovacsMaple Leaf Medical Clinic and Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Doron BetelApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065, USA; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Jeffry R JohnsonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029 USA.
Mirko PaiardiniEmory National Primate Research Center, Emory University, Atlanta, GA 30322 USA; Department of Pathology & Laboratory Medicine, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Ali DaneshInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
R Brad JonesInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Microbiology and Immunology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. Electronic address: rbjones@med.cornell.edu.
Funding
REACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9MERASE HIV: Enterprise for Research and Advancements to Stop and Eradicate HIVUM1AI164562 · NIAID · EMORY UNIVERSITY · PI Deanna A Kulpa, Mirko Paiardini · 2021 to 2026
$30.0MWeill Cornell Initiative for Maximizing Student DevelopmentR25GM130494 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CARRASCO, YAZMIN PAULINA, CESARMAN, ETHEL · 2019 to 2023
$2.4MCellular Determinants and Function Consequences of PP2A-B56 Degradation by HIV-1 VifR01AI167691 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jeffrey R Johnson · 2023 to 2026
$2.2MNIAID NIH HHS R01 AI167691NIAID NIH HHS UM1 AI164562NIAID NIH HHS UM1 AI164565NIGMS NIH HHS R25 GM130494
Abstract
Persistent HIV reservoirs in CD4
Indexed as
CD8-Positive T-LymphocytesEnhancer of Zeste Homolog 2 ProteinHIV-1HIV InfectionsImmune EvasionAnimalsBenzamidesBiphenyl CompoundsCD4-Positive T-LymphocytesHumansMiceMorpholinesPhenotypePyridonesT-Lymphocytes, CytotoxicVirus ReplicationBenzamidesBiphenyl CompoundsEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanMorpholinesPyridonestazemetostatCP: ImmunologyCP: Microbiologyepigenetic regulationEZH2HIVHIV cure researchHIV reservoirtazemetostatT cell exhaustionT cell immunity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.