Evidence map›Paper›PMID 40333133›Full record

ReviewPathogens (Basel, Switzerland)2025

From Microbial Ecology to Clinical Challenges: The Respiratory Microbiome's Role in Antibiotic Resistance.

Adelina-Gabriela Niculescu, Mihaela Magdalena Mitache, Alexandru Mihai Grumezescu, Mariana Carmen Chifiriuc, Mara Madalina Mihai, Monica Marilena Tantu, Ana Catalina Tantu, Loredana Gabriela Popa, Georgiana Alexandra Grigore, Roxana-Elena Cristian and 2 more

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adelina-Gabriela NiculescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.ORCID 0000-0001-8968-504X
Mihaela Magdalena MitacheDepartment of Preclinical Disciplines, Faculty of Medicine, Titu Maiorescu University, 031593 Bucharest, Romania.ORCID 0009-0008-8886-970X
Alexandru Mihai GrumezescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
Mariana Carmen ChifiriucResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 050663 Bucharest, Romania.ORCID 0000-0001-6098-1857
Mara Madalina MihaiFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0002-1436-0088
Monica Marilena TantuDepartment of Medical Assistance and Physical Therapy, Pitesti University Center, Târgu din Vale 1, 110040 Pitești, Romania.
Ana Catalina TantuDoctoral School, University of Medicine and Pharmacy of Craiova, Petru Rareș 2, 200349 Craiova, Romania.
Loredana Gabriela PopaMicrobiology Discipline II, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0002-8285-7176
Georgiana Alexandra GrigoreResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 050663 Bucharest, Romania.ORCID 0009-0004-8539-4885
Roxana-Elena CristianResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 050663 Bucharest, Romania.
Mircea Ioan PopaMicrobiology Discipline II, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0002-0794-9329
Corneliu Ovidiu VrancianuResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 050663 Bucharest, Romania.ORCID 0000-0002-2409-0966

Funding

; Ministry of Research, Innovation and Digitalization through the National Recovery and Resilience Plan (PNRR) of Romania Pillar III, Component C9/Investment no. 8 (I8) - contract CF 68The core program within the National Research Development and Innovation Plan, 2022-2027', carried out with the support of the Ministry of Research, Innovation and Digitalization (MCID) project no. 23020101, Contract no. 7N from 3 January 2023University of Bucharest CNFIS-FDI-2024-F-0484 INOVEX
6 · The paper itself

Abstract

Antibiotic resistance represents a growing public health threat, with airborne drug-resistant strains being especially alarming due to their ease of transmission and association with severe respiratory infections. The respiratory microbiome plays a pivotal role in maintaining respiratory health, influencing the dynamics of antibiotic resistance among airborne pathogenic microorganisms. In this context, this review proposes the exploration of the complex interplay between the respiratory microbiota and antimicrobial resistance, highlighting the implications of microbiome diversity in health and disease. Moreover, strategies to mitigate antibiotic resistance, including stewardship programs, alternatives to traditional antibiotics, probiotics, microbiota restoration techniques, and nanotechnology-based therapeutic interventions, are critically presented, setting an updated framework of current management options. Therefore, through a better understanding of respiratory microbiome roles in antibiotic resistance, alongside emerging therapeutic strategies, this paper aims to shed light on how the global health challenges posed by multi-drug-resistant pathogens can be addressed.

Indexed as

Drug Resistance, BacterialDrug Resistance, MicrobialMicrobiotaRespiratory SystemRespiratory Tract InfectionsAnti-Bacterial AgentsHumansProbioticsAnti-Bacterial Agentsalternative antimicrobialsantibiotic resistancegut–lung axismicrobial restorationprecision medicinerespiratory microbiomerespiratory pathogens

Identifiers

PMID40333133
PMCPMC12030467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.