Evidence map›Paper›PMID 40333016›Full record

ArticleJournal of the American Society of Nephrology : JASN2025

Fortifying the Diabetic Kidney Disease Treatment Armamentarium: Multitarget Senotherapeutic and Regenerative Strategies.

Helly A Patel, Jiaxuan Wang, Caroline J Zinn, Maya Learmonth, Lilach O Lerman, Joy Wolfram, LaTonya J Hickson

Registry-linked trialAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03840343 (Intra-arterially Delivered Autologous Mesenchymal Stem/Stromal Cell Therapy in Patients With Diabetic Kidney Disease), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03840343 phase1terminatednot on this map

Intra-arterially Delivered Autologous Mesenchymal Stem/Stromal Cell Therapy in Patients With Diabetic Kidney Disease: A Phase I Study

TypeinterventionalSponsorMayo ClinicRan2019 to 2020Enrolled2ConditionsDiabetic Kidney Disease, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1ArmsAutologous adipose-derived mesenchymal stem/stromal cells (MSC) Lower Dose, Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Higher Dose
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. A Randomized Clinical Trial of Kidney Autologous Cell Therapy in Diabetic Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helly A PatelDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.
Jiaxuan WangMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Jacksonville, Florida.ORCID 0009-0007-4099-5558
Caroline J ZinnDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-9099-172
Maya LearmonthMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-8534-0172
Lilach O LermanDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-3271-3887
Joy WolframSchool of Chemical Engineering, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0003-0579-9897
LaTonya J HicksonDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-7485-336

Funding

Extracellular vesicle-based senotherapeutics for aging diabetic kidneydiseaseR01AG076537 · NIA · MAYO CLINIC JACKSONVILLE · PI LaTonya J Hickson · 2023 to 2026
$2.3M
Mesenchymal stem cell senescence in diabetic nephropathy (K23 COVID Admin Supplement)K23DK109134 · NIDDK · MAYO CLINIC ROCHESTER · PI HICKSON, LATONYA J · 2016 to 2021
$1.0M
Renal repair effects of senolytic preconditioned mesenchymal stromal PP #o20-111cells in diabetic kidney diseaseR03DK123492 · NIDDK · MAYO CLINIC ROCHESTER · PI HICKSON, LATONYA J · 2020 to 2021
$467k
Mayo Clinic CTS Grant TL1TR002380NIA NIH HHS R01 AG076537NIDDK Diabetes Complications Consortium DK115255, DK076169NIDDK NIH HHS K23 DK109134NIDDK NIH HHS R03 DK123492NIH HHS AG076537NIH HHS DK101405, DK118120, DK07013, DK123492NIH HHS DK109134NIH HHS DK120292 and HL158691Regenerative Medicine Minnesota RMM 091718CT
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chronic inflammationdiabetes mellitusmacrophagesrenal fibrosisrenal stem cellstem cell

Identifiers

PMID40333016
PMCPMC12342067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.