Evidence map›Paper›PMID 40332985›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

Long-Term Outcome of Paediatric Crohn's Disease Patients With Deep Ulcerations at Diagnosis.

Monica S Ronconi, Antoine Neuraz, Elise Payen, Elie Abi Nader, Cécile Lambe, Florence Campeotto, Cécile Talbotec, Frank M Ruemmele, Bénédicte Pigneur

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Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Monica S RonconiService de Gastro-Entérologie et Nutrition Pédiatrique, Centre de Référence Des Maladies Rares Digestives (MARDI), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.
Antoine NeurazDepartment of Biostatistics, Imagine Institute, APHP, Paris, France.
Elise PayenService de Gastro-Entérologie et Nutrition Pédiatrique, Centre de Référence Des Maladies Rares Digestives (MARDI), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.
Elie Abi NaderService de Gastro-Entérologie et Nutrition Pédiatrique, Centre de Référence Des Maladies Rares Digestives (MARDI), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.
Cécile LambeService de Gastro-Entérologie et Nutrition Pédiatrique, Centre de Référence Des Maladies Rares Digestives (MARDI), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.
Florence CampeottoService de Gastro-Entérologie et Nutrition Pédiatrique, Centre de Référence Des Maladies Rares Digestives (MARDI), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.
Cécile TalbotecService de Gastro-Entérologie et Nutrition Pédiatrique, Centre de Référence Des Maladies Rares Digestives (MARDI), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.
Frank M RuemmeleService de Gastro-Entérologie et Nutrition Pédiatrique, Centre de Référence Des Maladies Rares Digestives (MARDI), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.
Bénédicte PigneurService de Gastro-Entérologie et Nutrition Pédiatrique, Centre de Référence Des Maladies Rares Digestives (MARDI), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université Paris Cité, Paris, France.ORCID 0000-0002-5324-9964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPresence of deep ulcerations (DU) at diagnosis seems to be predictive of a more severe phenotype in adult Crohn's disease (CD). The aim of our study was to investigate if the presence of DU at diagnosis was associated with a more severe disease course over time in children.

methodsIn this monocentric retrospective study, we analysed data from paediatric patients with a new diagnosis of CD from 2009 to 2017. Clinical, laboratory data, treatments and complications were recorded for each patient at diagnosis and at 1, 3 and 5 years of follow-up. Patients were compared according to the presence or absence of DU on colonoscopy.

resultsAmong the 116 patients included in the study, 52 patients had DU at diagnosis. Comparison showed an increased risk for patients with DU to develop abdominal abscesses (p = 0.045) and to experience more relapses (p = 0.013) at 1 year. At 3 and 5 years, there was no longer any difference between groups. The time from diagnosis to first anti-TNF alpha was shorter in DU patients.

conclusionThe presence of DU at diagnosis is associated with more complications during the first year of follow-up but not after, due to a more active therapeutic management.

Indexed as

Crohn DiseaseUlcerAdolescentChildFemaleFollow-Up StudiesHumansMaleRecurrenceRetrospective StudieschildrenendoscopyIBDprognostic factorulcerations

Identifiers

PMID40332985
PMCPMC12336948

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.