ReviewInsects2025
From Digestion to Detoxification: Exploring Plant Metabolite Impacts on Insect Enzyme Systems for Enhanced Pest Control.
Review in Insects, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Integrated Transcriptomic and Physiological Analyses Reveal Disruption of Digestive Homeostasis Induced by Protease Inhibitors in Anticarsia gemmatalis Caterpillars.Archives of insect biochemistry and physiology · 2026Article
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- Article
- Cytochrome P450-mediated regulation of pheromone biosynthesis and adult emergence in Monochamus saltuarius (Coleoptera, Cerambycidae), with implications for pest management.Pest management science · 2026Article
- Catalases act as putative oral secretion effectors in Tuta absoluta, suppressing tomato oxidative defenses and providing safe RNAi targets for pest control.Pest management science · 2026Article
- An Autolysis-Derived Trypsin Peptide Disrupts Digestive Homeostasis and Reduces Fitness inACS omega · 2026Article
- Insect-resistant soybean genotypes accumulate rutin and its O-methylated derivative narcissin, a more potent flavonol targeting Anticarsia gemmatalis digestive and detoxification enzymes and reducing larval survival.Journal of the science of food and agriculture · 2026Article
- Organ-Specific Responses to Plant Secondary Metabolites Reveal Mechanisms of Adaptation.Archives of insect biochemistry and physiology · 2026Article
- Integrative analysis of maize and sunflower responses to copper stress reveals species-specific phytoremediation strategies.BMC plant biology · 2026Article
- Combined toxicity of pesticides and heavy metals on Rhizoglyphus robini (Acari: Acaridae).Scientific reports · 2026Article
- GC-MS-Based Comparative Analysis of Compounds in Host Plants and Insect Gut Extracts.Metabolites · 2026Article
- Enhanced Toxicity, Physiological Disruption, and Population Growth Suppression Induced by NanoemulsifiedPlants (Basel, Switzerland) · 2026Article
- Integrated Pest Management Strategies for ControllingInsects · 2026Review
- Article
- The Activity ofToxins · 2026Article
- Pathophysiology and histological anomalies in testicular tissues of Calosoma olivieri exposed to heavy metals generated by pesticide industries.Scientific reports · 2026Article
- Comparative proteomics provides Insights into activation of jasmonic acid-mediated resistance mechanism in chickpea-Helicoverpa armigera interaction.Plant cell reports · 2026Article
- Synthetic Peptide Inhibition of Trypsin-Like Proteases in Spodoptera frugiperda (Lepidoptera: Noctuidae): Evaluating the Influence of Gut Microbiota.Archives of insect biochemistry and physiology · 2026Article
- Integrative transcriptomics and defense-related gene family analysis reveals key genes for maize resistance to fall armyworm.BMC plant biology · 2026Article
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review provides an in-depth examination of the intricate interactions between plant metabolites and the digestive and antioxidative enzymes in insects, highlighting their essential roles in shaping insect herbivory and adaptation strategies. Plants have evolved a diverse arsenal of secondary metabolites to defend against herbivorous insects, which, in response, have developed sophisticated adaptations to overcome these defenses and efficiently exploit plant resources. We outline the importance of digestive enzymes, such as proteases and amylases, which allow insects to break down complex plant compounds and access vital nutrients. Additionally, the review focuses on antioxidative enzymes in the insect midgut, including superoxide dismutase and catalase, which play a crucial role in mitigating oxidative stress generated during digestion and other metabolic processes. Synthesizing findings from various studies, this review also considers how environmental factors, such as heavy metal exposure and temperature changes, influence these enzymes' activity levels. It highlights the dual function of antioxidative enzymes in detoxifying harmful plant-derived compounds while preserving cellular stability. The implications of these biochemical interactions for pest management are discussed, with an emphasis on the potential for developing biopesticides that target specific enzymatic pathways to disrupt insect feeding and growth. By elucidating the biochemical mechanisms that underlie plant-insect interactions, this review enhances our understanding of co-evolutionary dynamics and offers insights into sustainable agricultural practices that could leverage these interactions for effective pest control. Finally, the review proposes future research directions aimed at identifying novel plant metabolites with enzyme-modulating properties and exploring the ecological impacts of enzyme-targeted pest management approaches.
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