Evidence map›Paper›PMID 40332812›Full record

ArticleInternational journal of molecular sciences2025

HCM-Associated MuRF1 Variants Compromise Ubiquitylation and Are Predicted to Alter Protein Structure.

Jitpisute Chunthorng-Orn, Maya Noureddine, Peter W J Dawson, Samuel O Lord, Jimi Ng, Luke Boyton, Katja Gehmlich, Fiyaz Mohammed, Yu-Chiang Lai

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jitpisute Chunthorng-OrnSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0009-0005-1140-6799
Maya NoureddineDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0009-0001-1890-5962
Peter W J DawsonSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-4315-7473
Samuel O LordCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.ORCID 0000-0002-6241-7966
Jimi NgCentre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Nottingham NG11 8NS, UK.
Luke BoytonSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Katja GehmlichDepartment of Cardiovascular Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-4019-1844
Fiyaz MohammedDepartment of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0002-9022-0132
Yu-Chiang LaiSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0002-8254-3732

Funding

British Heart Foundation AA/18/2/34218British Heart Foundation IA/F/23/275037Medical Research Council MR/V009540/1Medical Research Council MR/W007002/1MRC Versus Arthritis Centre for Musculoskeletal Aging Research MR/P021220/1
6 · The paper itself

Abstract

MuRF1 [muscle RING (Really Interesting New Gene)-finger protein-1] is an ubiquitin-protein ligase (E3), which encode by

Indexed as

Cardiomyopathy, HypertrophicMuscle ProteinsTripartite Motif ProteinsUbiquitinationUbiquitin-Protein LigasesConnectinHumansModels, MolecularMutationProtein BindingProtein ConformationConnectinMuscle ProteinsTRIM63 protein, humanTripartite Motif ProteinsUbiquitin-Protein Ligaseshypertrophic cardiomyopathyMuRF1MuRF1 domainspathogenic variantsstructural modellingTRIM63ubiquitylation

Identifiers

PMID40332812
PMCPMC12027535

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.