ArticleFish physiology and biochemistry2025
Curcumin's role in reshaping the redox dynamics of fish kidneys: NRF2 activation as a strategy against copper-induced nephropathy.
Article in Fish physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Sublethal Triclosan triggers oxidative stress and autophagy responses in Labeo rohita.Fish physiology and biochemistry · 2026Article
- Cadmium-induced changes in haemato-immunological, oxidative stress and antioxidant parameters of Cyprinus carpio: Protective role of curcumin.Journal of fish biology · 2026Article
- The interplay between inflammation and oxidative stress in depression: pathogenic mechanisms and treatment approaches.Molecular biology reports · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
From essential to harmful, excess copper compromises aquatic vitality. Curcumin, a potent antioxidant bioactive, counteracts heavy metal toxicity. This study examines its role in modulating the NRF2-KEAP1 pathway to boost antioxidant defenses and mitigate apoptosis in kidneys of Channa punctatus exposed to environmentally relevant Copper concentrations (ERCC). 180 fully habituated fish were categorized into six groups: Group 1 served as control, Group 2 was treated with 3 mg/L Curcumin, Group 3 was exposed to ERCC (0.85 mg/L Copper), while Group 4, Group 5 and Group 6 received co-exposure to ERCC along with the escalating Curcumin concentrations of 1 mg/L, 2 mg/L, and 3 mg/L, respectively, over periods of 15, 30, 45, 60, and 75 days. Biochemical assays were conducted to evaluate oxidative stress markers (Reactive oxygen species, reduced glutathione, glutathione peroxidase, and lipid peroxidation), kidney damage indicators (creatinine), and genotoxicity (micronuclei). Additionally, transcriptional profiling assessed mRNA levels of apoptosis-related factors (p53, bax, apaf1, cas9, cas3 and bcl2), while histopathological examinations revealed changes in renal architecture. Molecular docking analysis confirmed Curcumin's strong binding affinity to KEAP1, providing insights into its role in activating the NRF2-KEAP1 pathway. The results indicated that Curcumin significantly (p < 0.05) reduced Copper-induced oxidative stress, improved antioxidant defenses, suppressed genotoxicity, modulated apoptosis, and maintained renal tissue integrity. These findings validate curcumin's potential in effectively combating copper toxicity in aquaculture, paving the way for enhanced fish health and improved food safety.
Indexed as
Identifiers
40332669What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.