Evidence map›Paper›PMID 40332660›Full record

ArticleEuropean geriatric medicine2025

Association between early mobilization after hip fracture surgery and risk of long-term opioid therapy.

Yasmina Maria Tudorache, Ina Trolle Andersen, Thomas J Hjelholt, Morten Tange Kristensen, Katie J Sheehan, Alma B Pedersen

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Article in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yasmina Maria TudoracheDepartment of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Olof Palmes Alle 43-45, 8200 Aarhus N, Aarhus, Denmark.ORCID http://orcid.org/0009-0004-0131-4383
Ina Trolle AndersenDepartment of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Olof Palmes Alle 43-45, 8200 Aarhus N, Aarhus, Denmark.
Thomas J HjelholtDepartment of Geriatrics, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-0112-5801
Morten Tange KristensenDepartment of Physical and Occupational Therapy, Bispebjerg and Frederiksberg and Department of Clinical Medicine, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5868-4677
Katie J SheehanBone and Joint Health, Blizard Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-5325-7454
Alma B PedersenDepartment of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Olof Palmes Alle 43-45, 8200 Aarhus N, Aarhus, Denmark. abp@clin.au.dk.ORCID http://orcid.org/0000-0002-3288-9401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo examine the association between early mobilization after hip fracture surgery and the risk of long-term opioid therapy at 1-year follow-up.

findingsLong-term opioid therapy is a common complication after hip fracture surgery. Mobilization within 24 h after surgery is associated with a lower risk of long-term opioid therapy compared to mobilization between 24 and 36 h. MESSAGE: Early mobilization is one of the key elements of the successful patient recovery for reducing risk of complications and mortality after hip fracture surgery. PURPOSE: Early mobilization after hip fracture operation is associated with better clinical outcomes, but its impact on long-term opioid therapy (LTOT) remains unclear.

methodsUsing Danish population-based registries we included patients aged ≥ 65 who underwent surgery for a first-time hip fracture between 2016 and 2021 (n = 36,229). LTOT was defined as redeeming ≥ 2 prescriptions between 31 and 365 days of surgery. Using stabilized inverse probability of treatment (sIPT) weighing, we calculated risks and risk differences with 95% confidence intervals (CI) for opioid use balancing mobilization groups ≤ 24 h vs 24-36 h on measured confounders and taking death into consideration.

results67.3% of all patients were women and the median age was 82.6 years (75.8; 88.6). 75% of patients were mobilized ≤ 24 h of surgery, whereas 8% were mobilized between 24 and 36 h, 4.9% > 36 h, and 12.1% had missing data on mobilization. Patients mobilized ≤ 24 h and 24-36 h were similar in age, fracture type, and marital status, but those mobilized ≤ 24 h had fewer comorbidities, better pre-fracture mobility, and a higher social position. They also had a lower risk of LTOT (29.99%) compared to those mobilized 24-36 h (33.42%), with a weighted risk difference of 3.44% (95% CI 1.58-5.30).

conclusionsLTOT is common after hip fracture surgery. Mobilization ≤ 24 h after surgery is associated with a lower risk of LTOT compared to mobilization between 24 and 36 h. Early mobilization is one of the key elements of successful patient recovery for reducing complications and mortality after hip fracture surgery.

Indexed as

Analgesics, OpioidEarly AmbulationHip FracturesPostoperative PainAgedAged, 80 and overDenmarkFemaleHumansMaleRegistriesTime FactorsAnalgesics, OpioidEarly mobilizationEpidemiologyGeriatricsHip fractureOpioid useRehabilitation

Identifiers

PMID40332660
PMCPMC12174293

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.