Evidence map›Paper›PMID 40332622›Full record

ArticleMetabolic brain disease2025

Impact of chronic hyperglycemia and high-fat diet on Alzheimer's disease-related pathology in CX3CR1 knockout mice.

Andrew Adonay Ortiz, Andrew Scott Murtishaw, Monica Beckholt, Arnold Maloles Salazar, Amanda Marie Leisgang Osse, Jefferson William Kinney

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrew Adonay OrtizDepartment of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV, 89154, USA. Ortiza8@unlv.nevada.edu.
Andrew Scott MurtishawDepartment of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV, 89154, USA.
Monica BeckholtDepartment of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV, 89154, USA.
Arnold Maloles SalazarDepartment of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV, 89154, USA.
Amanda Marie Leisgang OsseDepartment of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV, 89154, USA.
Jefferson William KinneyDepartment of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Las Vegas, NV, 89154, USA.

Funding

NVEDARC Clinical CoreP20AG068053 · NIA · CLEVELAND CLINIC FOUNDATION · PI FOX, ROBERT J. · 2020 to 2022
$3.3M
Aging and hyperglycemia alter molecular mechanisms and hippocampal oscillations consistent with Alzheimer's diseaseR01AG062762 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI HYMAN, JAMES M., KINNEY, JEFFERSON · 2020 to 2021
$1.3M
NIA NIH HHS P20 AG068053NIA NIH HHS R01 AG062762
6 · The paper itself

Abstract

Diabetes mellitus (DM), obesity, and metabolic syndrome are related disorders with wide-ranging and devastating effects that are comorbid with many other diseases. Clinical and epidemiological studies have found that type II diabetes mellitus (T2DM), including chronic hyperglycemia and hyperinsulinemia, significantly increases the risk of Alzheimer's disease (AD) and other forms of dementia in the elderly. Insulin has slightly different functions in the peripheral body than in the central nervous system and the dysregulation of these functions may contribute to the onset and progression of late-life neurodegenerative disease. To investigate cognitive function and AD-related disease pathology, we utilized two different models of key features of diabetes, one model characterized by hyperglycemia resulting from a diabetogenic compound that selectively targets insulin-producing pancreatic β-cells, and the other model based on diet-induced obesity. Additionally, these diabetic models were combined with fractalkine receptor knockout mice (CX3CR1

Indexed as

Alzheimer DiseaseCX3C Chemokine Receptor 1Diet, High-FatHyperglycemiaAnimalsDisease Models, AnimalHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutObesityCX3C Chemokine Receptor 1Cx3cr1 protein, mouseAlzheimer’s diseaseDiabetesFractalkineHigh-fat dietHyperglycemiaNeuroinflammation

Identifiers

PMID40332622

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.