Evidence map›Paper›PMID 40332610›Full record

ArticleEuropean child & adolescent psychiatry2025

Duration of ADHD medication treatment among Finnish children and adolescents ‒ a nationwide register study.

Terhi A Kolari, Miika Vuori, Hanna Rättö, Eveliina A Varimo, Eeva T Aronen, Kari Auranen, Leena K Saastamoinen, Päivi T Ruokoniemi

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Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Terhi A KolariDepartment of Biostatistics and Turku University Hospital, University of Turku, Turku, Finland. terhi.kolari@utu.fi.
Miika VuoriThe Social Insurance Institution of Finland, Research Unit, Helsinki, Finland.
Hanna RättöThe Social Insurance Institution of Finland, Research Unit, Helsinki, Finland.
Eveliina A VarimoPediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland.
Eeva T AronenPediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland.
Kari AuranenDepartment of Mathematics and Statistics, University of Turku, Turku, Finland.
Leena K SaastamoinenInformation and Development Services, Finnish Medicines Agency, Helsinki, Finland.
Päivi T RuokoniemiDepartment of Clinical Pharmacology, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the duration of attention-deficit/hyperactivity disorder (ADHD) medication treatment among children and adolescents by sex and age group in Finland during 2008-2019.

methodsThis was a descriptive, population-based register study covering all Finnish children and adolescents aged 6-18 years who initiated their first ADHD medication treatment period between January 1, 2008 and December 31, 2019 (n = 40691). To establish the duration of use we collected data from the register of Dispensations reimbursable under the National Health Insurance Scheme register. The median follow-up time was 3.8 years (Q1 = 1.7, Q3 = 7.1). Treatment duration was calculated as the interval between the date of the first and last purchase with a cut-off of 365 days allowed between purchases. The durations were estimated using Kaplan-Meier survival times.

resultsThe median duration of ADHD medication treatment was 3.2 years (95% CI 3.2, 3.3, Q1 = 1.0 95% CI 0.9, 1.0, Q3 = 6.8 95% CI 6.7, 7.0). Sex and age significantly influenced treatment duration (p <.0001 and p <.0001). Boys had longer treatment duration than girls and the younger the subject, the longer the duration of usage. Boys aged 6-8 years (32.4% of the subjects) exhibited the longest treatment duration with a median of 6.3 years (95% CI 6.2, 6.5, Q1 = 2.6 95% CI 2.5, 2.7, Q3 = 9.4 years 95% CI 9.2, 9.6).

conclusionsThe duration of ADHD medication treatment among children in the real-world clinical setting goes well beyond the data available from randomized controlled trials and extends for several years especially among young boys.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsDuration of TherapyRegistriesAdolescentChildFemaleFinlandHumansMaleSex FactorsCentral Nervous System StimulantsADHDMedicine usePopulation basedRegistry studyReimbursement dataTreatment duration

Identifiers

PMID40332610
PMCPMC12592317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.