ArticleEuropean child & adolescent psychiatry2025
Abnormal alterations in neurodevelopment in preterm children with very low birth weight during the adolescence.
Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
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11 authors.
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Abstract
backgroundPreterm infants with very low birth weight are at high risk for long-term neurocognitive deficits. However, whether these neurocognitive deficits are improved or worsened in adolescence remains unclear.
methodsWe took advantage of the large sample from the Adolescent Brain Cognitive Development dataset to investigate alterations in brain structure, behavior, including cognitive function and mental health symptoms, and in puberty among preterm children with very low/normal birth weight (Pre_VLBW/Pre_NBW) and full-term children with normal birth weight (Con_NBW) from baseline to 2-year follow-up.
resultsPre_VLBW children relative to the other two groups had higher cortical thickness, lower cortical area and cortical/subcortical volumes in large portions of frontal cortex, temporal and occipital gyrus, insula, thalamus, and cerebellum; and attenuated fiber tract volumes in the fornix and foreceps major at baseline. Pre_VLBW children for their baseline measures also had lower cognitive function, higher pubertal levels and psychopathological risk. Furthermore, there were significant interaction effects on increased adrenarche score and cortical and subcortical volumes in medial orbitofrontal cortex (mOFC) and thalamus from baseline to 2-year follow-up. Pre_VLBW individuals showed higher adrenarche scores and lower volumes in the mOFC and thalamus than the other two groups at 2-year follow-up, but not at baseline. These brain structural changes showed associations with pubertal development levels, psychopathological risk and cognitive deficits.
conclusionThese findings support a view that preterm children with VLBW showed distinctive developmental alterations during adolescence, which potentially lead to long-lasting deviations in various brain regions and might be associated with behavioral problems and neurocognitive deficits.
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