Evidence map›Paper›PMID 40332606›Full record

ArticleBasic research in cardiology2025

A new mechanism of high-altitude adaptation reducing myocardium infarction: inhibiting inflammation-induced ubiquitin degradation of BK

Sen Wang, Yu Zhang, Wei-Cheng Yuan, Can-Yang Qi, Hua-Xing Zhang, Tian-Qi Wang, Hui-Jie Liu, Hai-Shuang Li, Yan-Ming Tian, Sheng Wang and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Basic research in cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sen Wang *Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yu Zhang *Department of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Wei-Cheng YuanDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Can-Yang QiDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Hua-Xing ZhangCore Facilities and Centers, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Tian-Qi WangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Hui-Jie LiuDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Hai-Shuang LiDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yan-Ming TianDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Sheng WangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Sui-Bing MiaoKey Laboratory of Maternal and Fetal Medicine of Hebei Province, The Fourth Hospital of Shijiazhuang Affiliated to Hebei Medical University, Shijiazhuang, 050011, China.
Li-Ping ZhangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Hui GuoDepartment of Gynaecology and Obstetrics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050010, China.
Xiang-Jian ZhangHebei Collaborative Innovation Center for Cardio-Cerebrovascular Disease, Shijiazhuang, 050017, China.
Yi ZhangDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China.
Huijie MaDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China. huijiema@hebmu.edu.cn.
Yue GuanDepartment of Physiology, Hebei Medical University, Shijiazhuang, 050017, China. guanyue@hebmu.edu.cn.

Funding

College student innovation project USIP2022165College student innovation project USIP2023035National Natural Science Foundation of China No.81800308Natural Science Foundation of Hebei Province No.C2021106015Natural Science Foundation of Hebei Province No.H2019206246Natural Science Foundation of Hebei Province for Innovative Research Group Project H2021206203
6 · The paper itself

Abstract

Our prior research demonstrated that chronic intermittent hypobaric hypoxia (CIHH) pretreatment confers cardioprotection against ischemia/reperfusion (I/R) injury in rats. However, the precise mechanisms underlying CIHH's cardioprotective effects remain insufficiently understood. This study aims to elucidate the upstream signaling pathways and dynamic regulation of BK

Indexed as

AltitudeCoronary VesselsHypoxiaLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMyocardial InfarctionUbiquitinVasodilationAdaptation, PhysiologicalAnimalsDisease Models, AnimalInflammationMaleProteolysisRatsRats, Sprague-DawleySignal TransductionKcnma1 protein, ratLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsUbiquitinChronic intermittent hypobaric hypoxiaCoronary flowLarge-conductance calcium-activated potassium channelMuRF1Nuclear factor kappa B

Identifiers

PMID40332606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.