Evidence map›Paper›PMID 40332599›Full record

Trial reportNeuroradiology2025

Comparative study between surgical drainage alone and adjuvant middle meningeal artery embolization with Histoacryl for the treatment and prevention of chronic subdural hematoma recurrence.

Luciano Bambini Manzato, José Ricardo Vanzin, Wagner Lazaretto Padua, Pedro Augusto Consalter, Vanessa Pereira, Felipe Perini, Daniel Giansante Abud

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luciano Bambini ManzatoFederal University of Fronteira Sul, Chapecó, Brazil. lbmanzato@hotmail.com.
José Ricardo VanzinFederal University of Fronteira Sul, Chapecó, Brazil.
Wagner Lazaretto PaduaFederal University of Fronteira Sul, Chapecó, Brazil.
Pedro Augusto ConsalterFederal University of Fronteira Sul, Chapecó, Brazil.
Vanessa PereiraFederal University of Fronteira Sul, Chapecó, Brazil.
Felipe PeriniFederal University of Fronteira Sul, Chapecó, Brazil.
Daniel Giansante AbudUniversidade de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe management of chronic subdural hematoma (CSDH) faces a high recurrence rate. Cohort studies have demonstrated a reduction in recurrence with middle meningeal artery embolization (MMAE). This study aims to demonstrate that this therapy is a safe and effective treatment and that, when combined with surgical drainage, it is superior to surgical treatment alone in reducing the recurrence rate.

methodsThis is a single-center, prospective, randomized study designed to evaluate the superiority of surgery followed by MMAE in reducing the recurrence rate of CSDH compared to surgery alone. A total of 76 hematomas were randomized in a 1:1 ratio to receive surgery followed by MMAE or conventional surgical treatment, with 69 patients evaluated at the end of the study. The primary outcome assessed was the recurrence rate of these hematomas within 90 days post-randomization.

resultsA total of 76 chronic subdural hematomas were included in this study, with 43 randomized to the control group and 33 to the intervention group. Hematoma recurrence within 90 days occurred in 1 patient (4.2%) in the intervention group compared to 4 patients (12.5%) in the control group (Absolute Risk Reduction, 8.3%; p = 0.379). The 90-day mortality rate was 6.1% in the intervention group and 11.6% in the control group (p = 0.434). No differences were observed in hospitalization duration or severe complication rates.

conclusionsIn symptomatic patients who underwent surgical treatment for CSDH drainage, the addition of MMA embolization showed a trend toward reducing the recurrence rate and 90-day mortality.

Indexed as

DrainageEmbolization, TherapeuticEnbucrilateHematoma, Subdural, ChronicMeningeal ArteriesAgedAged, 80 and overCombined Modality TherapyFemaleHumansMaleMiddle AgedProspective StudiesRecurrenceSecondary PreventionTreatment OutcomeEnbucrilateChronic subdural hematomaEmbolizationGlue HistoacrylMiddle menigeal artery

Identifiers

PMID40332599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.