Evidence map›Paper›PMID 40332590›Full record

ReviewInternational journal of molecular sciences2025

Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower.

Zhihua Wu, Yan Hu, Ruru Hao, Ruting Li, Xiaona Lu, Mdachi Winfrida Itale, Yang Yuan, Xiaoxian Zhu, Jiaqiang Zhang, Longxiang Wang and 2 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Experimental evaluation of the healing potential ofFrontiers in bioengineering and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhihua WuCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.ORCID 0000-0002-2895-7256
Yan HuCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Ruru HaoCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Ruting LiCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Xiaona LuCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Mdachi Winfrida ItaleCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Yang YuanNational Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan 430070, China.
Xiaoxian ZhuCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Jiaqiang ZhangZhejiang Institute of Landscape Plants and Flowers, Hangzhou 310053, China.ORCID 0009-0004-8790-7234
Longxiang WangCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.ORCID 0000-0001-7827-7366
Meihao SunCollege of Life Sciences, Zhejiang Normal University, Jinhua 321004, China.
Xianfei HouCrop Research Institute, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, China.

Funding

National Natural Science Foundation of China 32470395
6 · The paper itself

Abstract

Medicinal plants, recognized as significant natural resources, have gained prominence in response to the increasing global demand for herbal medicines, necessitating the large-scale production of these plants and their derivatives. Medicinal plants are exposed to a variety of internal and external factors that interact to influence the biosynthesis and accumulation of secondary metabolites. With the rapid development of omics technologies such as genomics, transcriptomics, proteomics, and metabolomics, multi-omics technologies have become important tools for revealing the complexity and functionality of organisms. They are conducive to further uncovering the biological activities of secondary metabolites in medicinal plants and clarifying the molecular mechanisms underlying the production of secondary metabolites. Also, artificial intelligence (AI) technology accelerates the comprehensive utilization of high-dimensional datasets and offers transformative potential for multi-omics analysis. However, there is currently no systematic review summarizing the genomic mechanisms of secondary metabolite biosynthesis in medicinal plants. Safflower (

Indexed as

Carthamus tinctoriusGenomicsPlants, MedicinalSecondary MetabolismFlavonoidsMetabolomicsFlavonoidsgenomicsmedicinal plantsregulationsafflowersecondary metabolites

Identifiers

PMID40332590
PMCPMC12027854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.