Evidence map›Paper›PMID 40332566›Full record

ArticleInternational journal of molecular sciences2025

Cucurbitacin B Exhibits Antitumor Effects on Chordoma Cells via Disruption of Brachyury.

Carolin Seeling, Johannes Neumahr, Fabian Häberle, André Lechel, Peter Möller, Nadine T Gaisa, Thomas F E Barth, Kevin Mellert

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carolin SeelingInstitute of Pathology, University Hospital Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Johannes NeumahrInstitute of Pathology, University Hospital Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Fabian HäberleInstitute of Pathology, University Hospital Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
André LechelDepartment of Internal Medicine I, University Hospital Ulm, 89081 Ulm, Germany.ORCID 0000-0003-0221-6959
Peter MöllerInstitute of Pathology, University Hospital Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Nadine T GaisaInstitute of Pathology, University Hospital Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Thomas F E BarthInstitute of Pathology, University Hospital Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Kevin MellertInstitute of Pathology, University Hospital Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0000-0001-6338-1857

Funding

Deutsche Forschungsgemeinschaft 441595227
6 · The paper itself

Abstract

Chordomas are rare malignant tumors of the bone, originating from remnants of notochordal cells. The transcription factor brachyury, encoded by

Indexed as

Antineoplastic AgentsChordomaFetal ProteinsT-Box Domain ProteinsTriterpenesApoptosisBrachyury ProteinCell Line, TumorCell ProliferationCell SurvivalGene Expression Regulation, NeoplasticHumansAntineoplastic AgentsBrachyury ProteinFetal ProteinsT-Box Domain ProteinsTriterpenesbrachyurychordomaCucurbitacin Bcytoskeletonprotein unfolding

Identifiers

PMID40332566
PMCPMC12028342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.