Evidence map›Paper›PMID 40332565›Full record

ArticleInternational journal of molecular sciences2025

Behavioral Effects of Stimulated Dopamine Release and D2-like Receptor Displacement in Parkinson's Patients with Impulse-Control Disorder.

Megan A Aumann, Sean J Lee, Alexander K Song, Kaitlyn R O'Rourke, Paula Trujillo, Yan Yan, Hakmook Kang, Daniel O Claassen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Megan A AumannDepartment of Neurology, Division of Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-3924-8455
Sean J LeeDepartment of Neurology, Division of Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Alexander K SongDepartment of Neurology, Division of Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-1590-4144
Kaitlyn R O'RourkeDepartment of Neurology, Division of Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Paula TrujilloDepartment of Neurology, Division of Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0001-9753-7071
Yan YanDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-0455-7450
Hakmook KangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Daniel O ClaassenDepartment of Neurology, Division of Behavioral and Cognitive Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-9853-4902

Funding

NIA NIH HHS 1K24AG064114NINDS NIH HHS 5R01NS097783
6 · The paper itself

Abstract

Dysregulated dopamine (DA) release in the mesocorticolimbic circuit is noted in Parkinson's disease (PD) patients with impulsive and compulsive behaviors (ICBs). However, the effect of acute DA release on mood, the localization of this process, and the phenotypic differences in patients with ICB remain unknown. We applied a placebo-controlled dextro-amphetamine (dAMPH) study in 20 PD patients: 10 with ICBs (PD-ICB) and 10 without (PD-C). Subjective mood experiences were measured with well-described self-reported measures including the Positive and Negative Affect Scale (PANAS), Drug Effects Questionnaire (DEQ), and Amphetamine Interview Rating Scale (AIRS). D2-like receptor availability was measured as non-displaceable binding potential (BP

Indexed as

Disruptive, Impulse Control, and Conduct DisordersDopamineParkinson DiseaseReceptors, Dopamine D2AgedDextroamphetamineFemaleHumansMaleMiddle AgedPositron-Emission TomographyDextroamphetamineDopamineReceptors, Dopamine D2amphetaminedopaminefallyprideimpulsivitymoodParkinson’s

Identifiers

PMID40332565
PMCPMC12027723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.