ReviewNaunyn-Schmiedeberg's archives of pharmacology2025
Herbal nanoparticles: bridging traditional medicine and modern science in epilepsy treatment.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Millions of people worldwide suffer from epilepsy, a persistent neurological illness characterized by recurring seizures. Despite advances in anti-epileptic medications, a significant number of patients continue to have insufficient seizure control and have side effects. Nanotechnology has emerged as a promising alternative for increasing medicine delivery and therapeutic effects in recent years. The anti-epileptic potential of nanoparticles produced from herbal medicines such as berberine-loaded zein/hyaluronic acid composite, Cannabis sativa extract-loaded nanoliposomes and nanostructured lipids, nanostructured lipid vehicle-carried safranal, and cryptolepine solid-lipid NPs is reviewed in this work, which makes use of the synergistic effects of nanotechnology and natural substances. The manuscript presents an overview of the mechanisms underlying the anti-epileptic effects of these nanoparticles, ranging from regulating neurotransmitter systems and ion channels to lowering oxidative stress and inflammation. Preclinical studies using animal models of epilepsy have shown that herbal medicine nanoparticles can reduce seizure activity, prolong seizure latency, and improve cognitive function. The findings presented in this manuscript highlight the remarkable potential of herbal medicine nanoparticles as a novel approach to the management of epilepsy. Continued research and development in this field have the potential to revolutionize epilepsy therapy and improve the quality of life for people suffering from this debilitating condition.
Indexed as
Identifiers
40332554What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.