Evidence map›Paper›PMID 40332547›Full record

ReviewInternational journal of molecular sciences2025

Potential Correlation Between Molecular Biomarkers and Oxidative Stress in Traumatic Brain Injury.

Cătălina Ionescu, Madalina Ghidersa, Alin Ciobica, Ioannis Mavroudis, Dimitrios Kazis, Foivos E Petridis, Dragoș Lucian Gorgan, Ioana-Miruna Balmus

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cătălina IonescuDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, 700505 Iasi, Romania.ORCID 0009-0008-4979-1057
Madalina GhidersaDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, 700505 Iasi, Romania.
Alin CiobicaDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, 700505 Iasi, Romania.
Ioannis MavroudisAcademy of Romanian Scientists, 050094 Bucharest, Romania.ORCID 0000-0001-9844-4010
Dimitrios KazisThird Department of Neurology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.ORCID 0000-0002-7319-2045
Foivos E PetridisThird Department of Neurology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.ORCID 0000-0002-5617-0346
Dragoș Lucian GorganDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, 700505 Iasi, Romania.ORCID 0000-0001-6454-9092
Ioana-Miruna BalmusDepartment of Exact Sciences and Natural Sciences, Institute of Interdisciplinary Research, "Alexandru Ioan Cuza" University of Iasi, 700057 Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosing traumatic brain injury (TBI) remains challenging due to an incomplete understanding of its neuropathological mechanisms. TBI is recognised as a complex condition involving both primary and secondary injuries. Although oxidative stress is a non-specific molecular phenomenon observed in various neuropathological conditions, it plays a crucial role in brain injury response and recovery. Due to these aspects, we aimed to evaluate the interaction between some known TBI molecular biomarkers and oxidative stress in providing evidence for its possible relevance in clinical diagnosis and outcome prediction. We found that while many of the currently validated molecular biomarkers interact with oxidative pathways, their patterns of variation could assist the diagnosis, prognosis, and outcomes prediction in TBI cases.

Indexed as

BiomarkersBrain Injuries, TraumaticOxidative StressHumansPrognosisBiomarkersbiomarkersdiagnosisoxidative stressprognosistraumatic brain injury

Identifiers

PMID40332547
PMCPMC12027598

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.