Evidence map›Paper›PMID 40332456›Full record

ArticleInternational journal of molecular sciences2025

Bacteria-Mediated Anomalous Rho GTPase Activation Alters Sperm Structure and Provokes Premature Capacitation Events: A Possible Mechanism of Infertility.

Bárbara Rivera, Claudia Aroca, Braian González, Neftalí Guzmán, Pablo Letelier, Pamela Uribe, Miguel Fornés, Juana Valentina Villegas, Rodrigo Boguen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bárbara RiveraLaboratorio de Investigación en Salud de Precisión, Departamento de Procesos Diagnósticos y Evaluación, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.ORCID 0009-0009-0787-1398
Claudia ArocaLaboratorio de Investigación en Salud de Precisión, Departamento de Procesos Diagnósticos y Evaluación, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.ORCID 0009-0006-7479-1062
Braian GonzálezLaboratorio de Investigación en Salud de Precisión, Departamento de Procesos Diagnósticos y Evaluación, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.
Neftalí GuzmánLaboratorio de Investigación en Salud de Precisión, Departamento de Procesos Diagnósticos y Evaluación, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.ORCID 0000-0003-4872-9821
Pablo LetelierLaboratorio de Investigación en Salud de Precisión, Departamento de Procesos Diagnósticos y Evaluación, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.
Pamela UribeDepartamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4780000, Chile.ORCID 0000-0001-7358-7541
Miguel FornésLaboratorio de Investigación de Andrología de Mendoza, Instituto de Histología y Embriología, Departamento de Morfología y fisiología, Escuela de Medicina, Universidad Nacional de Cuyo, CONICET, Mendoza M5500, Argentina.ORCID 0000-0002-8634-1396
Juana Valentina VillegasDepartamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4780000, Chile.
Rodrigo BoguenLaboratorio de Investigación en Salud de Precisión, Departamento de Procesos Diagnósticos y Evaluación, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.ORCID 0000-0002-0325-743X

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico 11201011Universidad Católica de Temuco 2023FEQUIP-RB-01Universidad Católica de Temuco VIPUCT-2018PF-RB-05Universidad de La Frontera DI17-0121
6 · The paper itself

Abstract

Male infertility is often linked to sperm quality issues; however, the mechanisms behind these alterations remain unclear in certain contexts. This study investigates the impact of anomalous Rho GTPase activation-a process triggered by bacterial toxins-on human sperm structure and function. Human spermatozoa were exposed in vitro to a Rho GTPase activator derived from

Indexed as

Escherichia coliInfertility, Malerho GTP-Binding ProteinsSpermatozoaSperm CapacitationAcrosome ReactionCalciumEnzyme ActivationHumansMaleMembrane Potential, MitochondrialSperm MotilityCalciumrho GTP-Binding Proteinsacrosome reactioncytotoxic necrotizing factor-1Escherichia colihuman spermatozoaRho GTPasessperm morphology

Identifiers

PMID40332456
PMCPMC12028253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.