Evidence map›Paper›PMID 40332455›Full record

ArticleInternational journal of molecular sciences2025

Secretome Release During In Vitro Bone Marrow-Derived Mesenchymal Stem Cell Differentiation Induced by Bio-Oss

Maria Rosa Iaquinta, Raffaella De Pace, Assia Benkhalqui, Antonio D'Agostino, Lorenzo Trevisiol, Alessia Finotti, Giulia Breveglieri, Mauro Tognon, Fernanda Martini, Elisa Mazzoni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Rosa IaquintaLaboratories of Cell Biology and Molecular Genetics, Section of Experimental Medicine, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-3242-859X
Raffaella De PaceDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0009-0005-1485-8950
Assia BenkhalquiSection of Dentistry and Maxillo-Facial Surgery, University of Verona, 37124 Verona, Italy.ORCID 0009-0004-3527-1553
Antonio D'AgostinoSection of Dentistry and Maxillo-Facial Surgery, University of Verona, 37124 Verona, Italy.
Lorenzo TrevisiolUnit of Maxillo-Facial Surgery, Santa Chiara Regional Hospital, Provincial Healthcare Services Agency (APSS), 38122 Trento, Italy.ORCID 0000-0002-2732-238X
Alessia FinottiDepartment of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-7638-515X
Giulia BreveglieriDepartment of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, 44121 Ferrara, Italy.
Mauro TognonLaboratories of Cell Biology and Molecular Genetics, Section of Experimental Medicine, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-8269-7937
Fernanda MartiniLaboratories of Cell Biology and Molecular Genetics, Section of Experimental Medicine, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Elisa MazzoniDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-6829-8569

Funding

Foundation Cariverona and Foundation Caritro 50457
6 · The paper itself

Abstract

Bone diseases represent a growing healthcare challenge due to population aging and lifestyle changes. Although bone has a natural regenerative capacity, approximately 10% of fractures fail to heal properly, requiring advanced therapeutic approaches. Bone tissue engineering (BTE) has advanced the use of osteoinductive and osteoconductive biomaterials to support bone regeneration. Among them, Bio-Oss

Indexed as

Bone Marrow CellsCell DifferentiationCollagenMesenchymal Stem CellsMineralsSecretomeAnimalsBiocompatible MaterialsBone RegenerationCattleCells, CulturedChondrogenesisCytokinesHumansOsteogenesisTissue EngineeringBiocompatible MaterialsBio-OssCollagenCytokinesMineralsbiomaterialbonecytokine/chemokinehydroxyapatite/collagenstem cell

Identifiers

PMID40332455
PMCPMC12027874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.