Evidence map›Paper›PMID 40332454›Full record

ReviewArchives of pharmacal research2025

Biodegradable gelatin methacryloyl microneedles: a new paradigm in transdermal drug delivery.

Khazanah Nurain Nurdin, Cecep Suhandi, Ahmed Fouad Abdelwahab Mohammed, Safwat A Mahmoud, Khaled M Elamin, Muchtaridi Muchtaridi, Nasrul Wathoni

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of pharmacal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Khazanah Nurain NurdinDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Cecep SuhandiDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Ahmed Fouad Abdelwahab MohammedDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61517, Egypt.
Safwat A MahmoudCenter for Scientific Research and Entrepreneurship, Northern Border University, 73213, Arar, Saudi Arabia.
Khaled M ElaminGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.
Muchtaridi MuchtaridiDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Nasrul WathoniDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, 45363, Indonesia. nasrul@unpad.ac.id.ORCID http://orcid.org/0000-0002-5985-6909

Funding

Northern Borders University NBU-FFR-2024-2292-05
6 · The paper itself

Abstract

Microneedles (MN) have emerged as a promising transdermal drug delivery technology that offers advantages such as minimal invasiveness, high biocompatibility, and biodegradability. Gelatin methacryloyl (GelMA)-based MNs have gained attention because of their flexibility, mechanical strength, and modification capabilities, which support controlled drug release. The synthesis process of GelMA involves crosslinking using UV light, resulting in a stable hydrogel structure that supports therapeutic applications, such as wound healing, cancer therapy, and glucose monitoring. However, challenges such as skin penetration strength, drug-loading capacity, and regulatory standards still require solutions. Material and design innovations, particularly the combination of GelMA with nanomaterials and natural polymers, have the potential to enhance the MN efficiency and expand its applications in various medical fields. This review explores the latest developments in GelMA-based MN design and their future potential as reliable therapeutic devices.

Indexed as

Drug Delivery SystemsGelatinMethacrylatesMicroinjectionsNeedlesAdministration, CutaneousAnimalsHumansHydrogelsSkinSkin AbsorptionGelatingelatin methacryloylHydrogelsMethacrylatesBiocompatibilityBiodegradabilityGelatin methacryloylHydrogelMicroneedleTransdermal drug delivery

Identifiers

PMID40332454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.