Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Manivannan YegambaramCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL 34987-2352, USA.ORCID 0000-0003-4561-8608
Marissa D PokharelCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL 34987-2352, USA.ORCID 0000-0002-6566-1817
Xutong SunCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL 34987-2352, USA.
Qing LuCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL 34987-2352, USA.
Jamie SotoCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL 34987-2352, USA.ORCID 0009-0007-9944-681X
Saurabh AggarwalDepartment of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Emin MaltepeDepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA.
Jeffery R FinemanDepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-9740-405X
Ting WangCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL 34987-2352, USA.
Stephen M BlackCenter for Translational Science, Florida International University, 11350 SW Village Parkway, Port St. Lucie, FL 34987-2352, USA.
Funding
TGF-ß-SOX18-Collagen metabolism in pulmonary vascular disease associated with CHDP01HL146369 · NHLBI · UNIVERSITY OF ARIZONA · PI JEFFREY R FINEMAN · 2020 to 2026
$18.7M
PERINATAL REGULATION OF THE ENDOTHELIAL NOS GENER01HL060190 · NHLBI · UNIVERSITY OF MONTANA · PI Stephen M Black · 1998 to 2026
$7.1M
Integrating Environmental Cues at the Maternal-Fetal Vascular InterfaceR01HD072455 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALTEPE, EMIN · 2012 to 2023
$4.3M
FIU-Diversity Center for Genomic Research (FIU-DCGR)UG3HG013615 · NHGRI · FLORIDA INTERNATIONAL UNIVERSITY · PI BLACK, STEPHEN M, WANG, XUEXIA · 2024 to 2024
It is well-established that mitochondrial dysfunction plays a critical role in the development of pulmonary hypertension (PH). However, the molecular mechanisms and how the individual electron transport complexes (ETC) may be affected are poorly understood. In this study, we identified decreased ETC Complex I activity and assembly and linked these changes to disrupted mitochondrial bioenergetics in pulmonary arterial endothelial cells (PAECs) isolated from a lamb model of PH with increased pulmonary blood flow (Shunt). These derangements were associated with decreased mitochondrial activity of the protein tyrosine kinase, pp60
Indexed as
Electron Transport Complex IEndothelial CellsHypertension, Pulmonarysrc-Family KinasesAmino Acid SequenceAnimalsCells, CulturedCell SeparationHumansMitochondriaProtein BindingRNA, Small InterferingSequence AlignmentSheepElectron Transport Complex IRNA, Small Interferingsrc-Family Kinasescomplex Imass spectrometrymitochondriaphosphorylationpp60Src kinasepulmonary hypertension
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.