Evidence map›Paper›PMID 40332440›Full record

ArticleInternational journal of molecular sciences2025

Ionic and Non-Ionic Counterparts Based on Bis(Uracilyl)Alkane Moiety with Highest Selectivity Towards Acetylcholinesterase for Protection Against Organophosphate Poisoning and Treating Alzheimer's Disease.

Irina V Zueva, Liliya F Saifina, Liliya M Gubaidullina, Marina M Shulaeva, Alexandra D Kharlamova, Oksana A Lenina, Grigory P Belyaev, Albina Y Ziganshina, Shan Gao, Wenjian Tang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irina V ZuevaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.ORCID 0000-0002-0518-0384
Liliya F SaifinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.ORCID 0000-0001-7504-1331
Liliya M GubaidullinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.
Marina M ShulaevaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.ORCID 0000-0001-6014-0177
Alexandra D KharlamovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.
Oksana A LeninaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.ORCID 0000-0002-3831-7367
Grigory P BelyaevArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.ORCID 0000-0003-3157-3402
Albina Y ZiganshinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.ORCID 0000-0003-4507-9923
Shan GaoSchool of Pharmacy, Anhui Medical University, Hefei 230032, China.
Wenjian TangSchool of Pharmacy, Anhui Medical University, Hefei 230032, China.
Vyacheslav E SemenovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.ORCID 0000-0001-8350-2433
Konstantin A PetrovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS Arbuzov str., 8, Kazan 420088, Russia.

Funding

Russian Science Foundation 24-75-10086
6 · The paper itself

Abstract

A series of bisuracils, in which uracil and 3,6-dimethyluracil moieties were bridged with a polymethylene spacer, and the uracil moiety contained a pentamethylene radical with ionic and non-ionic aminobenzyl groups, were synthesised. These bisuracils have been identified as cholinesterase inhibitors with exceptional selectivity for acetylcholinesterase (AChE) over butyrylcholinesterase (BuChE). These bisuracils, which have been identified as highly effective AChE inhibitors, demonstrated activity at nano- and sub-nanomolar concentrations, with exceptional selectivity for AChE over BuChE. In kinetic studies of lead bisuracils

Indexed as

AcetylcholinesteraseAlkanesAlzheimer DiseaseCholinesterase InhibitorsOrganophosphate PoisoningUracilAnimalsButyrylcholinesteraseHumansMaleMiceMolecular Docking SimulationMolecular Dynamics SimulationAcetylcholinesteraseAlkanesButyrylcholinesteraseCholinesterase InhibitorsUracil6-methyluracil derivativesacetylcholinesteraseAlzheimer’s diseasebutyrylcholinesteraseorganophosphate poisoningperipheral anionic site

Identifiers

PMID40332440
PMCPMC12027946

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.