ArticleInternational journal of molecular sciences2025
Pharmacologic ROMK Inhibition Protects Against Myocardial Ischemia Reperfusion Injury.
Allison C Wexler, Holly Dooge, Lara Serban, Aditya Tewari, Babak M Tehrani, Francisco J Alvarado, Mohun Ramratnam
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Allison C WexlerDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Holly DoogeDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Lara SerbanDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Aditya TewariDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.ORCID 0009-0001-9955-3013 Babak M TehraniDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Francisco J AlvaradoDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Mohun RamratnamDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Funding
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MPartial and Controlled Depletion of SR Calcium by RyR Agonists Prevents Calcium-dependent ArrhythmiasR01HL167195 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado, Hector H Valdivia · 2023 to 2026
$2.4MMechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathyR01HL161070 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado · 2022 to 2026
$1.9MNCATS NIH HHS UL1 TR002373NHLBI NIH HHS R01 HL161070NHLBI NIH HHS R01 HL167195NIH HHS 1R01HL161070-23A1NIH HHS 1R01HL167195-23A1NIH HHS 1UL1TR002373-21A1United States Department of Veterans Affairs 5IK2BX004614-05
6 · The paper itselfAbstract
Mitochondrial ATP-sensitive K+ channels are closely linked to cardioprotection and are potential therapeutic targets during ischemia reperfusion (IR) injury. The renal outer medullary K+ channel isoform 2 (ROMK2) is an ATP-sensitive K+ channel found in the mitochondria of cardiomyocytes. While the germline knockout of ROMK does not mediate myocardial IR injury, the effect of ROMK loss of function on IR injury in the adult myocardium is unknown. By using a selective small molecule inhibitor of ROMK, we paradoxically found that mouse hearts were protected from IR injury after ROMK inhibition compared to vehicle-treated animals. In addition, we found that ROMK inhibition leads to exaggerated mitochondrial uncoupling and increased ROS production. Phosphatidylinositol 4,5-bisphosphate (PIP
Indexed as
Cardiotonic AgentsMyocardial Reperfusion InjuryPotassium Channels, Inwardly RectifyingAdenosine TriphosphateAnimalsMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMitochondria, HeartMyocytes, CardiacReactive Oxygen SpeciesAdenosine TriphosphateCardiotonic AgentsPotassium Channels, Inwardly RectifyingReactive Oxygen SpeciesKATP channelmitoKATPmyocardial ischemic reperfusion injuryrenal outer medullary potassium channel
Identifiers
PMID40332433
PMCPMC12028082
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