Evidence map›Paper›PMID 40332417›Full record

ArticleInternational journal of molecular sciences2025

The Role of Hippo Signaling in Brain Arteriovenous Malformations: Molecular Insights into Post-Embolization Remodeling.

Belal Neyazi, Vanessa Magdalena Swiatek, Mohammad Ali Karimpour, Sarah Stassen, Klaus-Peter Stein, Ali Rashidi, Claudia Alexandra Dumitru, I Erol Sandalcioglu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Belal NeyaziDepartment of Neurosurgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0002-3163-0545
Vanessa Magdalena SwiatekDepartment of Neurosurgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Mohammad Ali KarimpourDepartment of Neurosurgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0002-7589-9984
Sarah StassenDepartment of Neurosurgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Klaus-Peter SteinDepartment of Neurosurgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Ali RashidiDepartment of Neurosurgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Claudia Alexandra DumitruDepartment of Neurosurgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0003-2075-9164
I Erol SandalciogluDepartment of Neurosurgery, Otto-von-Guericke University, 39120 Magdeburg, Germany.ORCID 0000-0002-5541-2411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain arteriovenous malformations (bAVMs) are complex vascular lesions with significant clinical risks. The Hippo signaling pathway, particularly its downstream effector YAP, plays a crucial role in angiogenesis and vascular remodeling. This study investigates the role of YAP and related molecular markers in bAVMs, focusing on the effects of embolization. Immunohistochemical analysis was conducted on tissue samples from bAVM patients (n = 127), as well as on healthy blood vessels (n = 17). YAP, HIF-1α, FGFR1, CTGF, and CYR61 expression were quantified and correlated with clinical parameters. Results: In healthy vessels, YAP exhibited nuclear localization in (sub)endothelial cells and the tunica media, while CTGF and CYR61 were detected in the cytoplasm and extracellular matrix. The expression of YAP, CTGF, and CYR61 was significantly lower in bAVM tissues. Embolized bAVMs exhibited significantly higher expression of YAP, CTGF, and CYR61 compared to non-embolized tissues, suggesting a link between embolization and pro-angiogenic signaling. Additionally, FGFR1 was upregulated in embolized tissues. These results suggest that upregulation of YAP expression via the Hippo pathway might play a key role in bAVM pathophysiology. Embolization may further promote vascular remodeling. Dysregulation of YAP and related molecules in bAVMs warrants further studies to explore potential therapeutic strategies targeting the Hippo pathway.

Indexed as

Embolization, TherapeuticIntracranial Arteriovenous MalformationsProtein Serine-Threonine KinasesSignal TransductionAdaptor Proteins, Signal TransducingAdolescentAdultConnective Tissue Growth FactorCysteine-Rich Protein 61FemaleHippo Signaling PathwayHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiddle AgedReceptor, Fibroblast Growth Factor, Type 1Adaptor Proteins, Signal TransducingCCN1 protein, humanCCN2 protein, humanConnective Tissue Growth FactorCysteine-Rich Protein 61FGFR1 protein, humanHypoxia-Inducible Factor 1, alpha SubunitProtein Serine-Threonine KinasesReceptor, Fibroblast Growth Factor, Type 1Transcription FactorsYAP1 protein, humanYAP-Signaling Proteinsbrain arteriovenous malformationconnective tissue growth factorcysteine-rich angiogenic inducer 61embolizationYes-associated protein

Identifiers

PMID40332417
PMCPMC12028238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.