Evidence map›Paper›PMID 40332408›Full record

ArticleInternational journal of molecular sciences2025

PERK/Sestrin2 Signaling Pathway Mediated Autophagy Regulates Human Cardiomyocytes Apoptosis Induced by Traffic-Related PM

Jiayu Tian, Zeyu Niu, Huan Yang, Caihong Wang, Linlin Guan, Lifang Zhao, Dongxing Shi, Zhihong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayu TianDepartment of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China.
Zeyu NiuDepartment of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China.
Huan YangDepartment of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China.
Caihong WangDepartment of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China.
Linlin GuanDepartment of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China.
Lifang ZhaoDepartment of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China.
Dongxing ShiDepartment of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China.
Zhihong ZhangDepartment of Environmental Health, School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China.ORCID 0000-0003-4458-1065

Funding

the Central Leading Local Science and Technology Development Funding Project YDZJSX2021A028the National Natural Science Foundation of China 82273595
6 · The paper itself

Abstract

Although the strong causal association between PM

Indexed as

ApoptosisAutophagyeIF-2 KinaseMyocytes, CardiacNuclear ProteinsParticulate MatterSignal TransductionCell LineEndoplasmic Reticulum StressHumansSestrinsEIF2AK3 protein, humaneIF-2 KinaseNuclear ProteinsParticulate MatterSESN2 protein, humanSestrinsapoptosisautophagycardiotoxicityPERK/Sestrin2traffic-related PM2.5

Identifiers

PMID40332408
PMCPMC12027522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.