Evidence map›Paper›PMID 40332392›Full record

ReviewInternational journal of molecular sciences2025

BRAF Targeting Across Solid Tumors: Molecular Aspects and Clinical Applications.

Hiba Mechahougui, James Gutmans, Roumaïssa Gouasmi, Laure Smekens, Alex Friedlaender

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Rare, Yet Targetable: New Perspectives on Ampullary Carcinomas.International journal of molecular sciences · 2026
    Review
  7. Review
  8. TargetingBiotechnologia · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hiba MechahouguiOncology Department, Geneva University Hospital (HUG), 1205 Geneva, Switzerland.ORCID 0009-0005-9784-0333
James GutmansOncology Department, Geneva University Hospital (HUG), 1205 Geneva, Switzerland.ORCID 0009-0006-9050-2267
Roumaïssa GouasmiCancer Research Center of Lyon, CNRS UMR5286, Inserm U1052, University of Lyon, 69100 Lyon, France.
Laure SmekensOncology Department, Geneva University Hospital (HUG), 1205 Geneva, Switzerland.
Alex FriedlaenderClinique Générale Beaulieu, 1206 Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BRAF mutations are critical drivers in cancers such as melanoma, colorectal cancer, and non-small-cell lung cancer. The most common mutation,

Indexed as

NeoplasmsProtein Kinase InhibitorsProto-Oncogene Proteins B-rafAnimalsDrug Resistance, NeoplasmHumansMolecular Targeted TherapyMutationTumor MicroenvironmentBRAF protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins B-rafBRAFmolecular oncologyprecision oncologytargeted therapytissue specificity

Identifiers

PMID40332392
PMCPMC12027668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.