Evidence map›Paper›PMID 40332387›Full record

ArticleInternational journal of molecular sciences2025

TMEM16A Maintains Acrosomal Integrity Through ERK1/2, RhoA, and Actin Cytoskeleton During Capacitation.

Ana L Roa-Espitia, Tania Reyes-Miguel, Monica L Salgado-Lucio, Joaquín Cordero-Martínez, Dennis Tafoya-Domínguez, Enrique O Hernández-González

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana L Roa-EspitiaDepartment of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute, México Av. Instituto Politécnico Nacional 2508, México City 07360, Mexico.
Tania Reyes-MiguelDepartment of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute, México Av. Instituto Politécnico Nacional 2508, México City 07360, Mexico.
Monica L Salgado-LucioDepartment of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute, México Av. Instituto Politécnico Nacional 2508, México City 07360, Mexico.ORCID 0000-0003-0832-6681
Joaquín Cordero-MartínezDepartment of Biochemistry, National School of Biological Sciences, National Polytechnic Institute, Prolongación Manuel Carpio y Plan de Ayala s/n Col, Santo Tomás, Del. Miguel Hidalgo, México City 07738, Mexico.ORCID 0000-0002-1302-6790
Dennis Tafoya-DomínguezDepartment of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute, México Av. Instituto Politécnico Nacional 2508, México City 07360, Mexico.
Enrique O Hernández-GonzálezDepartment of Cell Biology, Center of Research and Advanced Studies of the National Polytechnic Institute, México Av. Instituto Politécnico Nacional 2508, México City 07360, Mexico.

Funding

Consejo Nacional de Humanidades, Ciencia y Tecnología (CO-NAHCYT) . 284183-B and CBF-2023-2024-1894 to E.O.H.-G; Scholarship 367954 and 263011 to M.L.S.-L.
6 · The paper itself

Abstract

Mammalian spermatozoa undergo a series of physiological and biochemical changes in the oviduct that lead them to acquire the ability to fertilize eggs. During their transit in the oviduct, spermatozoa face a series of environmental changes that can affect sperm viability. A series of ion channels and transporters, as well as the sperm cytoskeleton, allow spermatozoa to remain viable and functional. Cl

Indexed as

AcrosomeActin CytoskeletonAnoctamin-1MAP Kinase Signaling SystemrhoA GTP-Binding ProteinSperm CapacitationAcrosome ReactionAnimalsChloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorMaleMiceSpermatozoaANO1 protein, mouseAnoctamin-1Chloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorrhoA GTP-Binding Proteinacrosome structurebicarbonate influxchloride channelsfertilizationsperm

Identifiers

PMID40332387
PMCPMC12027809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.