Evidence map›Paper›PMID 40332313›Full record

ArticleInternational journal of molecular sciences2025

Paeoniflorin Directly Targets ENO1 to Inhibit M1 Polarization of Microglia/Macrophages and Ameliorates EAE Disease.

Ying Sun, Guojue Wang, Shengzhe Li, Yongshuai Jiang, Yunhui Liu, Yidan Gao, Yuanyang Yuan, Hong Nie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Enolase-1 and Inflammation.Biomolecules · 2026
    Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying SunShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0002-4947-9783
Guojue WangShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shengzhe LiShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yongshuai JiangShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yunhui LiuShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yidan GaoShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0009-0009-7961-0824
Yuanyang YuanShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Hong NieShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Funding

National Natural Science Foundation of China 82371809Shanghai Institute of Immunology Fund
6 · The paper itself

Abstract

The chronic autoimmune disease multiple sclerosis (MS) now remains incurable. Paeoniflorin (PF), which is a monoterpene glucoside obtained from

Indexed as

DNA-Binding ProteinsEncephalomyelitis, Autoimmune, ExperimentalGlucosidesMacrophagesMicrogliaMonoterpenesPhosphopyruvate HydrataseTumor Suppressor ProteinsAnimalsDisease Models, AnimalFemaleGlucoseGlycosidesMiceMice, Inbred C57BLDNA-Binding ProteinsEno1 protein, mouseGlucoseGlucosidesGlycosidesMonoterpenespeoniflorinPhosphopyruvate HydrataseTumor Suppressor ProteinsEAEENO1glucose metabolismmicroglia/macrophage polarizationpaeoniflorin

Identifiers

PMID40332313
PMCPMC12027182

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.