Evidence map›Paper›PMID 40332279›Full record

ArticleInternational journal of molecular sciences2025

Identifying Genes Associated with the Anticancer Activity of a Fluorinated Chalcone in Triple-Negative Breast Cancer Cells Using Bioinformatics Tools.

Eduardo De la Cruz-Cano, José Ángel González-Díaz, Ivonne María Olivares-Corichi, Jorge Tonatiuh Ayala-Sumuano, José Alfredo Díaz-Gandarilla, Quirino Torres-Sauret, Violeta Larios-Serrato, Miguel Ángel Vilchis-Reyes, Carlos Javier López-Victorio, José Arnold González-Garrido and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eduardo De la Cruz-CanoLaboratorio de Bioquímica y Biología Molecular, División Académica de Ciencias Básicas, Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), Universidad Juárez Autónoma de Tabasco, Cunduacán C.P. 86690, Mexico.ORCID 0000-0002-1972-6317
José Ángel González-DíazLaboratorio de Bioquímica y Biología Molecular, División Académica de Ciencias Básicas, Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), Universidad Juárez Autónoma de Tabasco, Cunduacán C.P. 86690, Mexico.
Ivonne María Olivares-CorichiLaboratorio de Oncología Molecular y Estrés Oxidativo, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México C.P. 11340, Mexico.ORCID 0000-0002-5608-048X
Jorge Tonatiuh Ayala-SumuanoIDIX Biotechnology, SA. de C.V. Querétaro, Querétaro C.P. 76235, Mexico.ORCID 0000-0001-7008-2978
José Alfredo Díaz-GandarillaLaboratorio de Análisis Clínicos, División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco C.P. 86650, Mexico.ORCID 0000-0001-9109-3246
Quirino Torres-SauretLaboratorio de Bioquímica y Biología Molecular, División Académica de Ciencias Básicas, Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), Universidad Juárez Autónoma de Tabasco, Cunduacán C.P. 86690, Mexico.ORCID 0000-0003-3294-7664
Violeta Larios-SerratoLaboratorio de Biotecnología Genómica y Bioinformática, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México C.P. 11340, Mexico.
Miguel Ángel Vilchis-ReyesLaboratorio de Bioquímica y Biología Molecular, División Académica de Ciencias Básicas, Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), Universidad Juárez Autónoma de Tabasco, Cunduacán C.P. 86690, Mexico.ORCID 0000-0002-5624-5096
Carlos Javier López-VictorioLaboratorio de Bioquímica y Biología Molecular, División Académica de Ciencias Básicas, Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), Universidad Juárez Autónoma de Tabasco, Cunduacán C.P. 86690, Mexico.ORCID 0000-0002-0703-7266
José Arnold González-GarridoLaboratorio de Bioquímica y Biología Molecular, División Académica de Ciencias Básicas, Centro de Investigación de Ciencia y Tecnología Aplicada de Tabasco (CICTAT), Universidad Juárez Autónoma de Tabasco, Cunduacán C.P. 86690, Mexico.ORCID 0000-0003-1135-4050
José Rubén García-SánchezLaboratorio de Oncología Molecular y Estrés Oxidativo, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México C.P. 11340, Mexico.ORCID 0000-0003-4381-8243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorinated chalcones are molecules reported to possess potent anticancer properties against triple-negative breast cancer (TNBC) cells. However, their molecular mechanisms have not yet been fully explored. Using bioinformatics tools, we analyzed the transcriptomes of MDA-MB-231 cells treated with either a novel fluorinated chalcone (compound

Indexed as

Antineoplastic AgentsChalconeChalconesComputational BiologyGene Expression Regulation, NeoplasticTriple Negative Breast NeoplasmsCell Line, TumorFemaleGene Expression ProfilingHumansTranscriptomeAntineoplastic AgentsChalconeChalconesbioinformatic toolsDE genesfluorinated chalconeTNBC

Identifiers

PMID40332279
PMCPMC12027753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.