Evidence map›Paper›PMID 40332246›Full record

ArticleInternational journal of molecular sciences2025

Improved Synthesis of Effective 3-(Indolin-6-yl)-4-(

Konstantin V Potapov, Dmitry N Platonov, Alexander Yu Belyy, Maxim A Novikov, Yury V Tomilov, Anastasia A Anashkina, Kristina A Mukhina, Olga I Kechko, Pavel N Solyev, Roman A Novikov and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Konstantin V PotapovEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0003-3819-2418
Dmitry N PlatonovZelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-9331-7319
Alexander Yu BelyyZelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-4948-6238
Maxim A NovikovEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Yury V TomilovZelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-3433-7571
Anastasia A AnashkinaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0003-1763-300X
Kristina A MukhinaEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Olga I KechkoEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Pavel N SolyevEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-5546-4975
Roman A NovikovEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Alexander A MakarovEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.
Vladimir A MitkevichEngelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-1517-1983

Funding

the Russian Science Foundation 19-74-30007
6 · The paper itself

Abstract

NADPH oxidase enzymes (NOXs) are a family of enzymes generating superoxide, which form reactive oxygen species. NOX2 activity is a causative agent for the progression of many diseases: neurodegenerative, cardiovascular, immune dysregulations, and even hereditary diseases and cancer. Administering antioxidants helps in inhibiting NOX2 activity; however, the development of selective inhibitors may provide greater improvement in the therapy of diseases. Here, an optimized synthesis of two most promising NOX2 inhibitors based on the 3-(indolin-6-yl)-4-(

Indexed as

Enzyme InhibitorsNADPH Oxidase 2PyrazolesPyridinesSulfonamidesAmyloid beta-PeptidesAnimalsHumansMicrogliaAmyloid beta-PeptidesEnzyme InhibitorsNADPH Oxidase 2PyrazolesPyridinesSulfonamidesAlzheimer’s diseaseGSK2795039microglial cellsNOX2 inhibitorreactive oxygen species

Identifiers

PMID40332246
PMCPMC12026636

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.