Evidence map›Paper›PMID 40332245›Full record

ArticleInternational journal of molecular sciences2025

Novel Link Between Myeloid-Specific Adenosine Deaminase 2 and CXCL10-CXCR3 Axis in Infectious ARDS.

Shilpa Tiwari-Heckler, Yered Pita-Juarez, Lisa Vierbaum, Patrick Michl, Ioannis S Vlachos, Uta Merle, Z Gordon Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shilpa Tiwari-HecklerDepartment of Gastroenterology, Infectiology and Toxicology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Yered Pita-JuarezDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Lisa VierbaumDepartment of Gastroenterology, Infectiology and Toxicology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-3661-6512
Patrick MichlDepartment of Gastroenterology, Infectiology and Toxicology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-0401-5600
Ioannis S VlachosDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Uta MerleDepartment of Gastroenterology, Infectiology and Toxicology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-1386-3350
Z Gordon JiangDepartment of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Funding

Cholesterol toxicity in alcohol-associated hepatitisR01AA030770 · NIAAA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Zhenghui Gordon Jiang · 2023 to 2026
$2.7M
German Center for Infection Research TI 07.005NIAAA NIH HHS R01 AA030770
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is a severe complication of lung injury characterized by hyperinflammation and fibrosis. Here, we show a significant association between the monocyte-derived enzyme adenosine deaminase 2 (ADA2) and SARS-CoV-2 induced ARDS. We note an interesting link between ADA2 and the chemokine CXCL10 and its receptor CXCR3. By using published datasets of spatial transcriptomics and single-cell RNAseq, we show that ADA2 is highly expressed by inflammatory CD14

Indexed as

Adenosine DeaminaseChemokine CXCL10COVID-19Receptors, CXCR3Respiratory Distress SyndromeHumansIntercellular Signaling Peptides and ProteinsLungMonocytesSARS-CoV-2Signal TransductionADA2 protein, humanAdenosine DeaminaseChemokine CXCL10CXCL10 protein, humanCXCR3 protein, humanIntercellular Signaling Peptides and ProteinsReceptors, CXCR3ARDSCOVID-19infiltrative monocytespurinergic signaling

Identifiers

PMID40332245
PMCPMC12027617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.