Evidence map›Paper›PMID 40332214›Full record

ArticleInternational journal of molecular sciences2025

Elevated Serum Protein Induced by Vitamin K Absence or Antagonist II Levels in Patients with Hepatic Hemangiomas.

Shigeo Maruyama, Tomomitsu Matono, Masahiko Koda

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shigeo MaruyamaMaruyama Medical Clinic, Aioi-cho 3921, Hamada 697-0034, Shimane, Japan.
Tomomitsu MatonoDepartment of Gastroenterology, Hyogo Prefectural Harima-Himeji General Hospital, Kamiya-cho 364, Himeji 670-8560, Hyogo, Japan.
Masahiko KodaHino Hospital, Nota 332, Hino 689-4504, Tottori, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Little is known about the effect of hepatic hemangiomas on protein induced by vitamin K absence or antagonist II (PIVKA-II). The aim of this study was to clarify the correlation of PIVKA-II levels with hepatic hemangiomas. In 335 consecutive patients with hepatic hemangiomas, ultrasonography (US), laboratory tests for liver function, serum levels of PIVKA-II and α-fetoprotein (AFP), and coagulation factors (platelets, prothrombin time (PT), fibrinogen, thrombin-antithrombin III complex (TAT), D-dimer, and fibrin and fibrinogen degradation products (FDPs)) as indicators of coagulation disorders were examined. PIVKA-II levels were significantly higher in the hemangioma group than in the control group (

Indexed as

BiomarkersBlood ProteinsHemangiomaLiver NeoplasmsProtein PrecursorsAdultAgedBlood Coagulation FactorsFemaleHumansMaleMiddle AgedProthrombinVitamin KacarboxyprothrombinBiomarkersBlood Coagulation FactorsBlood ProteinsProtein PrecursorsProthrombinVitamin Kcoagulation disordershepatic hemangiomaPIVKA-IIprothrombin

Identifiers

PMID40332214
PMCPMC12027271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.