Evidence map›Paper›PMID 40332165›Full record

ArticleCritical care science2025

Evaluation of prognostic factors for mortality in cancer patients with sepsis in the intensive care unit: systematic review protocol.

María Fernanda García-Aguilera, Nayely García-Méndez, Glenn Hernández, Borja M Fernández-Félix, Harold Alexander-León, Yunqi Yu-Liu, Josue Rivadeneira, Luis Fuenmayor-González, Cristopher Isaac Peña Robayo, Fernanda Villalba and 9 more

Abstract read
In one paragraph

Article in Critical care science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Impact of intensive care unit admission on the resumption of treatment in patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

María Fernanda García-AguileraUniversidad de La Frontera - Temuco, Chile.ORCID http://orcid.org/0000-0002-5375-3474
Nayely García-MéndezUniversidad de La Frontera - Temuco, Chile.ORCID http://orcid.org/0000-0002-2251-8148
Glenn HernándezDepartment of Intensive Care Medicine, School of Medicine, Pontificia Universidad Católica de Chile - Santiago, Chile.ORCID http://orcid.org/0000-0002-3032-4087
Borja M Fernández-FélixClinical Biostatistics Unit, Hospital Universitario Ramón y Cajal - Madrid, Spain.ORCID http://orcid.org/0000-0002-8798-019X
Harold Alexander-LeónHospital Oncológico SOLCA, Núcleo de Quito - Quito, Ecuador.ORCID http://orcid.org/0000-0001-6261-636X
Yunqi Yu-LiuHospital Oncológico SOLCA, Núcleo de Quito - Quito, Ecuador.ORCID http://orcid.org/0009-0003-3148-5530
Josue RivadeneiraUniversidad de La Frontera - Temuco, Chile.ORCID http://orcid.org/0000-0002-3930-252X
Luis Fuenmayor-GonzálezFaculty of Medical Sciences, Universidad Central del Ecuador - Quito, Ecuador.ORCID http://orcid.org/0000-0001-6141-7692
Cristopher Isaac Peña RobayoFaculty of Medical Sciences, Universidad Central del Ecuador - Quito, Ecuador.ORCID http://orcid.org/0009-0007-1169-9215
Fernanda VillalbaZero Biomedical Research - Quito, Ecuador.ORCID http://orcid.org/0009-0009-4370-0764
Eduardo Andrés Aragundi PalaciosUniversidad Católica de Santiago de Guayaquil - Guayaquil, Ecuador.ORCID http://orcid.org/0009-0001-9185-8648
Emérita Eugenia Basantes BorjaFaculty of Medical Sciences, Universidad Central del Ecuador - Quito, Ecuador.ORCID http://orcid.org/0000-0002-3349-2238
Henry Caballero NarvaezHospital Oncológico SOLCA, Núcleo de Quito - Quito, Ecuador.ORCID http://orcid.org/0000-0003-3466-975X
Isabel Morales AlcocerFaculty of Medical Sciences, Universidad Central del Ecuador - Quito, Ecuador.ORCID http://orcid.org/0009-0005-0166-8197
Eduardo VelazcoFaculty of Medical Sciences, Universidad Central del Ecuador - Quito, Ecuador.ORCID http://orcid.org/0000-0001-7896-3868
Georgina MuñozUniversidad de La Frontera - Temuco, Chile.ORCID http://orcid.org/0000-0001-7372-9861
Juan Pablo Holguín-CarvajalUniversidad de La Frontera - Temuco, Chile.ORCID http://orcid.org/0000-0002-6844-3962
Tamara Otzen HernándezUniversidad de La Frontera - Temuco, Chile.ORCID http://orcid.org/0000-0001-6014-1241
Carlos ManterolaUniversidad de La Frontera - Temuco, Chile.ORCID http://orcid.org/0000-0001-9213-2905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis systematic review outlines a comprehensive approach to identify and analyze prognostic factors associated with mortality in adult cancer patients with sepsis in the intensive care unit. The review will focus on all-cause 28-day mortality, and where not available, we will use 30-day, intensive care unit, or in-hospital mortality. METHODS AND ANALYSIS: We present a protocol for the systematic review of prognostic factors for mortality in adult cancer patients with sepsis managed in the intensive care unit. Our primary outcome is 28-day mortality, and where not available, we will use 30-day, intensive care unit, or in-hospital mortality. The secondary outcome is the global mortality incidence. Studies on the basis of the population (sepsis and neoplasms), prognostic study methods and outcome of interest (mortality) will be included. We will search the following databases: Medline, PubMed, EMBASE, SCOPUS, Web of Science, and Bireme-BVS, until April 5, 2024. The risk of bias will be assessed using the QUIPS tool. A meta-analysis will be conducted where possible to generate pooled estimates for identified prognostic factors. Two authors will independently assess the risk of bias in each study using the Quality in Prognostic Studies tool. The GRADE approach will be employed to evaluate the overall quality of evidence and the strength of the recommendations. Findings will be disseminated through publication in a peer-reviewed journal. This review aims to provide clinicians with valuable insights into factors influencing mortality risk in this high-risk population, ultimately informing clinical decision-making and improving patient outcomes. ETHICS AND SOCIALIZATION: The results of this review will be published in a peer-reviewed scientific journal. Does not require ethical approval.

Indexed as

Intensive Care UnitsNeoplasmsSepsisHospital MortalityHumansPrognosisResearch DesignSystematic Reviews as Topic

Identifiers

PMID40332165
PMCPMC12040416

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.