Evidence map›Paper›PMID 40332125›Full record

ArticleInternational journal of molecular sciences2025

Claudin-17 Deficiency Drives Vascular Permeability and Inflammation Causing Lung Injury.

Mir S Adil, Varun Parvathagiri, Abdulaziz H Alanazi, Daulat Khulood, S Priya Narayanan, Payaningal R Somanath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mir S AdilProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0002-2129-1228
Varun ParvathagiriProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Abdulaziz H AlanaziProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
Daulat KhuloodProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.
S Priya NarayananProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0002-8842-622X
Payaningal R SomanathProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912, USA.ORCID 0000-0003-3017-0230

Funding

NIH HHS 1UL1TR002378-22A1
6 · The paper itself

Abstract

The role of claudin-17 (Cldn17), a tight-junction protein, in vascular permeability remains unclear. We investigated the impact of Cldn17 suppression on vascular permeability. The Miles assay demonstrated significantly increased vascular permeability in the lungs and skin of

Indexed as

Capillary PermeabilityClaudinsInflammationLung InjuryPneumoniaAnimalsLipopolysaccharidesLungMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionClaudinsLipopolysaccharidesCldn17inflammationlung injurypulmonary edemavascular permeability

Identifiers

PMID40332125
PMCPMC12027279

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.