Evidence map›Paper›PMID 40332099›Full record

ArticleInternational journal of molecular sciences2025

Multi-Omic Analysis Reveals the Potential Anti-Disease Mechanism of Disease-Resistant Grass Carp.

Chongqing Wang, Zeyang Li, Xu Huang, Xidan Xu, Xiaowei Xu, Kun Zhang, Yue Zhou, Jinhai Bai, Zhengkun Liu, Yuchen Jiang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Chongqing WangEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Zeyang LiEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Xu HuangEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Xidan XuEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Xiaowei XuEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Kun ZhangEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.ORCID 0000-0001-6435-5386
Yue ZhouEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Jinhai BaiEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Zhengkun LiuEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Yuchen JiangEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Yan TangEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Xinyi DengEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Siyang LiEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Enkui HuEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Wanjing PengEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Ling XiongEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Qian XiaoEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Yuhan YangEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Qinbo QinEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Shaojun LiuEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education, Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.

Funding

Earmarked Fund for China Agriculture Research System CARS-45Earmarked Fund for HARS HARS-07National Key Research and Development Program of China 2023YFD2401601Special Funds for the Construction of Innovative Province in Hunan 2023WK2001Special Science Found of Nansha-South China Agricultural University Fishery Research Institute, Guangzhou NSYYKY202305
6 · The paper itself

Abstract

The gut-liver axis is essential in animal disease and health. However, the role of the gut-liver axis in the anti-disease mechanism of disease-resistant grass carp (DRGC) derived from the backcross of female gynogenetic grass carp (GGC) and male grass carp (GC) remains unclear. This study analyzed the changes in gut histopathology, fecal intestinal microflora and metabolites, and liver transcriptome between GC and DRGC. Histological analysis revealed significant differences in the gut between DRGC and GC. In addition, microbial community analyses indicated that hybridization induced gut microbiome variation by significantly increasing the proportion of Firmicutes and Bacteroidota in DRGC. Metabolomic data revealed that the hybridization-induced metabolic change was probably characterized by being related to taurocholate and sphinganine in DRGC. Transcriptome analysis suggested that the enhanced disease resistance of DRGC was primarily attributed to immune-related genes (

Indexed as

CarpsDisease ResistanceFish DiseasesGastrointestinal MicrobiomeAnimalsFemaleGene Expression ProfilingLiverMaleMetabolomicsMultiomicsTranscriptomedisease-resistant grass carpgut–liver axisintestinal microflorametabolitestranscriptome

Identifiers

PMID40332099
PMCPMC12027461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.