ArticleInternational journal of molecular sciences2025
α2-Adrenergic Receptors in Hypothalamic Dopaminergic Neurons: Impact on Food Intake and Energy Expenditure.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The adrenergic system plays an active role in modulating synaptic transmission in hypothalamic neurocircuitry. While α2-adrenergic receptors are widely distributed in various organs and are involved in various physiological functions, their specific role in the regulation of energy metabolism in the brain remains incompletely understood. Herein, we investigated the functions of α2-adrenergic receptors in the hypothalamus on energy metabolism in mice. Our study confirmed the expression of α2-adrenergic receptors in hypothalamic dopaminergic neurons and assessed metabolic phenotypes, including food intake and energy expenditure, after treatment with guanabenz, an α2-adrenergic receptor agonist. Guanabenz treatment significantly increased food intake (0.25 ± 0.03 g vs. 0.98 ± 0.05 g,
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