Evidence map›Paper›PMID 40332054›Full record

ArticleInternational journal of molecular sciences2025

Protect Effects of Perilla Seed Extract and Its Active Ingredient Luteolin Against Inflammatory Bowel Disease Model via the PI3K/AKT Signal Pathway In Vivo and In Vitro.

Jin Zhang, Linlu Zhao, Jieyi He, Huining Wu, Mengru Guo, Zhichao Yu, Xingbin Ma, Yanhong Yong, Youquan Li, Xianghong Ju and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jin ZhangDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.ORCID 0009-0009-8082-8142
Linlu ZhaoDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.
Jieyi HeDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.
Huining WuDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.
Mengru GuoDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.
Zhichao YuDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.ORCID 0000-0002-8910-4089
Xingbin MaDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.
Yanhong YongDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.
Youquan LiDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.
Xianghong JuDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.
Xiaoxi LiuDepartment of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524091, China.ORCID 0000-0002-4533-5221

Funding

Nanhai Scholars Program of Guangdong Ocean University 002029002005National Natural Science Foundation of China 31902314, 32273077Program for Scientiffc Research Start-Up Funds of Guangdong Ocean University 101402/R17088
6 · The paper itself

Abstract

The purpose of this study was to investigate the anti-inflammatory effects of Perilla Seed Extract (PSE) and its active ingredient on Inflammatory Bowel Disease (IBD) in vitro and in vivo. Thirty-two C57/BL mice were randomly divided into four groups (

Indexed as

Inflammatory Bowel DiseasesPerillaPhosphatidylinositol 3-KinasesPlant ExtractsProto-Oncogene Proteins c-aktSeedsSignal TransductionAnimalsDisease Models, AnimalLipopolysaccharidesMaleMiceMice, Inbred C57BLLipopolysaccharidesPhosphatidylinositol 3-KinasesPlant ExtractsProto-Oncogene Proteins c-aktIBDluteolinnetwork pharmacologyperilla seed extracttranscriptomics analysis

Identifiers

PMID40332054
PMCPMC12026851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.