Evidence map›Paper›PMID 40332013›Full record

ArticleInternational journal of molecular sciences2025

Environmental Factors Exacerbate Parkinsonian Phenotypes in an Asian-Specific Knock-In LRRK2 Risk Variant in Mice.

Zoë Bichler, Sarivin Vanan, Zhiwei Zhang, Qianying Sally Dong, Jolene Wei Ling Lee, Chengwu Zhang, Liting Hang, Mei Jiang, Parasuraman Padmanabhan, Wuan Ting Saw and 5 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zoë BichlerBehavioural Neuroscience Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Sarivin VananNeural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.ORCID 0000-0002-9114-4952
Zhiwei ZhangNeural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Qianying Sally DongBehavioural Neuroscience Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.ORCID 0009-0004-6642-5201
Jolene Wei Ling LeeNeural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.ORCID 0009-0000-8644-7839
Chengwu ZhangNeurodegeneration Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Liting HangNeurodegeneration Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Mei JiangNeural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Parasuraman PadmanabhanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0003-4112-4600
Wuan Ting SawNeuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.
Zhidong ZhouNeuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.ORCID 0000-0003-0251-4163
Balázs GulyásLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
Kah Leong LimLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0002-5440-2588
Li ZengNeural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, Singapore.
Eng King TanNeuroscience and Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore 169857, Singapore.

Funding

National Medical Research Council LCG002-SPARK IINational Medical Research Council MOH-CIRG21nov-0001
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder affecting nearly 10 million people worldwide, and for which no cure is currently known. Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene, age, as well as environmental factors such as neurotoxin exposure and stress, are known to increase the risk of developing the disease in humans. To investigate the role of a specific Asian variant of the LRRK2 gene to induce susceptibility to stress and trigger PD phenotypes with time, knock-in (KI) mice bearing the human LRRK2 R1628P risk variant have been generated and studied from 2 to 16 months of age in the presence (or absence) of stress insults, including neurotoxin injections and chronic mild stress applied at 3 months of age. Pathophysiological and behavioural phenotypes have been measured at different ages and primary neurons and fibroblast cells were cultured from the KI mouse line and treated with H

Indexed as

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseAnimalsDisease Models, AnimalDopamineFibroblastsGene Knock-In TechniquesGenetic Predisposition to DiseaseHumansMaleMiceMice, TransgenicMutationNeuronsOxidative StressPhenotypeDopamineLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanLrrk2 protein, mouseAsian specific variantbehaviourenvironmental toxinsLRRK2oxidative stressParkinson’s diseasephysiological stress

Identifiers

PMID40332013
PMCPMC12027425

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.