Evidence map›Paper›PMID 40331991›Full record

ArticleInternational journal of molecular sciences2025

Expression of Estrogen Receptors in Main Immune Organs in Sheep During Early Pregnancy.

Zhen Yang, Yaqi Zhang, Zhihong Cao, Zhouyuan Li, Leying Zhang, Ling Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhen YangSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.
Yaqi ZhangSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.
Zhihong CaoSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.
Zhouyuan LiSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.
Leying ZhangSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.ORCID 0000-0002-8612-8325
Ling YangSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.ORCID 0000-0003-4385-0024

Funding

Hebei Postgraduate Innovation Ability Funding Project CXZZSS2025087Natural Science Foundation of Hebei Province, China C2024402023
6 · The paper itself

Abstract

Estrogen exerts its action via estrogen receptors (ERs), including ERα and ERβ, and has effects on immunomodulation during pregnancy. It is known that there are changes in the function of the maternal immune organs during pregnancy. However, it is not clear if early pregnancy has effects on the expression of ERα and ERβ in the ovine maternal thymus, lymph nodes, spleen, and liver. In this study, these maternal immune organs were harvested at day 16 of the estrous cycle and at days 13, 16, and 25 of pregnancy (n = 6 for each group) after the ewes were euthanized. The mRNA and protein expression of ERα and ERβ were analyzed using real-time PCR and Western blot and immunohistochemical analyses. The results reveal that the mRNA and protein expression of both ERα and ERβ were upregulated in the maternal spleen and the expression of ERα and ERβ in the thymus, lymph nodes, and liver was modulated during early pregnancy. In conclusion, early pregnancy modulates the expression of ERα and ERβ in the maternal thymus, lymph nodes, spleen, and liver in a tissue-specific manner, which is related to the regulation of maternal immune function during early pregnancy in ewes.

Indexed as

Estrogen Receptor alphaEstrogen Receptor betaReceptors, EstrogenAnimalsFemaleLiverLymph NodesPregnancyRNA, MessengerSheepSpleenThymus GlandEstrogen Receptor alphaEstrogen Receptor betaReceptors, EstrogenRNA, Messengerestrogen receptorimmune organpregnancysheep

Identifiers

PMID40331991
PMCPMC12027075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.