Evidence map›Paper›PMID 40331971›Full record

ArticleJournal of medicinal chemistry2025

New Insights into the French Paradox: Free Radical Scavenging by Resveratrol Yields Cardiovascular Protective Metabolites.

Orinamhe G Agbadua, Norbert Kúsz, Róbert Berkecz, Elemér Vass, Antal Csámpai, Gábor Tóth, György T Balogh, Laurence Marcourt, Jean-Luc Wolfender, Emerson Ferreira Queiroz and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Orinamhe G AgbaduaInstitute of Pharmacognosy, University of Szeged, Eötvös str. 6, H-6720 Szeged, Hungary.
Norbert KúszInstitute of Pharmacognosy, University of Szeged, Eötvös str. 6, H-6720 Szeged, Hungary.
Róbert BerkeczInstitute of Pharmaceutical Analysis, University of Szeged, Somogyi str. 4, H-6720 Szeged, Hungary.ORCID 0000-0002-9076-2177
Elemér VassDepartment of Organic Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/a, H-1117 Budapest, Hungary.
Antal CsámpaiDepartment of Organic Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/a, H-1117 Budapest, Hungary.
Gábor TóthNMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, H-1111 Budapest, Hungary.
György T BaloghDepartment of Pharmaceutical Chemistry, Semmelweis University, H-1092 Budapest, Hungary.ORCID 0000-0001-8273-1760
Laurence MarcourtSchool of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva, Switzerland.ORCID 0000-0002-9614-1099
Jean-Luc WolfenderSchool of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva, Switzerland.ORCID 0000-0002-0125-952X
Emerson Ferreira QueirozSchool of Pharmaceutical Sciences, University of Geneva, CMU, 1211 Geneva, Switzerland.
Attila HunyadiInstitute of Pharmacognosy, University of Szeged, Eötvös str. 6, H-6720 Szeged, Hungary.ORCID 0000-0003-0074-3472

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol was subjected to a diversity-oriented synthesis using oxidative transformations by various biorelevant, biomimetic, or biomimetic-related chemical reagents. Using a combined strategy of ultrahigh-resolution profiling, bioactivity screening, and bioactivity-guided isolation, 19 metabolites were obtained. The compounds were tested for their

Indexed as

BenzofuransFree Radical ScavengersStilbenesAngiotensin-Converting Enzyme InhibitorsArachidonate 15-LipoxygenaseCyclooxygenase 1Cyclooxygenase 2HumansLipoxygenase InhibitorsPeptidyl-Dipeptidase AResveratrolStructure-Activity RelationshipAngiotensin-Converting Enzyme InhibitorsArachidonate 15-LipoxygenaseBenzofuransCyclooxygenase 1Cyclooxygenase 2epsilon-viniferinFree Radical ScavengersLipoxygenase InhibitorsPeptidyl-Dipeptidase AResveratrolStilbenes

Identifiers

PMID40331971
PMCPMC12105021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.