Evidence map›Paper›PMID 40331826›Full record

ArticlemBio2025

Characterization of the family-level

Kalya M Socarras, Mary C Marino, Joshua P Earl, Rachel L Ehrlich, Nicholas A Cramer, Joshua C Mell, Bhaswati Sen, Azad Ahmed, Richard T Marconi, Garth D Ehrlich

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Prevalence ofPathogens (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kalya M SocarrasCenter for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Mary C MarinoCenter for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Joshua P EarlCenter for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9830-5173
Rachel L EhrlichCenter for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Nicholas A CramerDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA.
Joshua C MellCenter for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Bhaswati SenCenter for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Azad AhmedCenter for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Richard T MarconiDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA.ORCID 0000-0002-6035-7306
Garth D EhrlichCenter for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-0341-8771

Funding

MAPP Research NetworkU01DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2008 to 2018
$17.2M
MOLECULAR ANALYSIS OF PATHOGENS IN OTITIS MEDIA BY PCRR01DC002148 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EHRLICH, GARTH D. · 1994 to 2017
$6.5M
Limited Competition for Continuation of the MAPP-RN DCCU24DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2019 to 2021
$4.9M
PlzA, cyclic-di-GMP and the enzootic cycle for Lyme diseaseU01AI169840 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI Christopher Davies, RICHARD T MARCONI · 2023 to 2026
$2.8M
Chimeric epitope based vaccines for tick borne infectionsR01AI141801 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2019 to 2022
$2.5M
OspC and its role in defining host range and dissemination propertiesR01AI165876 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2022 to 2025
$2.2M
Bill an Marian Cook FoundationNational Institute of Allergy and Infectious Diseases AI 141801National Institute of Allergy and Infectious Diseases AI 165876NIAID NIH HHS R01 AI141801NIAID NIH HHS R01 AI165876NIAID NIH HHS U01 AI169840NIDCD NIH HHS DC 01248NIDCD NIH HHS R01 DC002148NIDDK NIH HHS DK 082316NIDDK NIH HHS U01 DK082316NIDDK NIH HHS U24 DK082316Oskar Fischer Project
6 · The paper itself

Abstract

The IMPORTANCE: Using whole genome sequencing, we demonstrated that the bacteria that are transmitted by ticks and other arthropod vectors that cause Lyme disease and relapsing fevers, while related, do not belong within the same genus classification. In addition, through characterization of their highly atypical genomic structure, we were able to develop a genetic typing system that will help with future studies of how they cause disease while also providing targets for medical interventions.

Indexed as

Genome, BacterialPlasmidsAnimalsHumansLyme DiseasePhylogenyBorreliaBorreliaceaeBorreliellacomparative genomicsdistributed genome hypothesispan-genomephylogeneticsspirochetesupragenometaxonomy

Identifiers

PMID40331826
PMCPMC12153284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.