Evidence map›Paper›PMID 40331415›Full record

ArticleSmall methods2025

Fabrication of Microneedles by Pulsating In Situ Dried Electrostretching for Transdermal Drug Delivery.

Ngoc Luan Mai, Yuen Yong, Thi Van Anh Hoang, Trung Hieu Vu, Hoai-Duc Vu, Van Canh Doan, Donglin Cai, Thien Xuan Dinh, Dzung Viet Dao, Van Thanh Dau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ngoc Luan MaiSchool of Engineering and Built Environment, Griffith University, Queensland, 4215, Australia.ORCID https://orcid.org/0000-0003-2296-2254
Yuen YongSchool of Engineering, The University of Newcastle, NSW, 2308, Australia.
Thi Van Anh HoangSchool of Engineering and Built Environment, Griffith University, Queensland, 4215, Australia.
Trung Hieu VuSchool of Engineering and Built Environment, Griffith University, Queensland, 4215, Australia.
Hoai-Duc VuSchool of Engineering and Built Environment, Griffith University, Queensland, 4215, Australia.
Van Canh DoanSchool of Engineering and Built Environment, Griffith University, Queensland, 4215, Australia.
Donglin CaiSchool of Medicine and Dentistry, Griffith University, Queensland, 4215, Australia.
Thien Xuan DinhThe Commonwealth Scientific and Industrial Research Organisation, Clayton, 3168, Australia.
Dzung Viet DaoSchool of Engineering and Built Environment, Griffith University, Queensland, 4215, Australia.ORCID https://orcid.org/0000-0002-6348-0879
Van Thanh DauSchool of Engineering and Built Environment, Griffith University, Queensland, 4215, Australia.

Funding

Australian Research Council DP230100637Australian Research Council DP240101559
6 · The paper itself

Abstract

This paper introduces a novel pulsating in situ dried electrostretching (PIDES) technique for the fabrication of microneedles (MNs) for transdermal drug delivery. This method utilizes pulsed voltage to induce electrohydrodynamic forces that stretch and freeze a polymer droplet into a conical shape with a micrometer-scale tip. With the effects of solvent evaporation, the polymeric droplet is in situ stretched into a conical shape and solidified, transforming into a sharp MN, suitable for transdermal drug administration. Penetration and mechanical tests confirm that the MNs possess sufficient sharpness and strength for effective skin penetration applications. Additionally, curcumin loading and in vitro release tests with different concentrations demonstrate the MNs' ability to carry drugs and exhibit effective controlled release profiles. These findings highlight PIDES as a promising, low-cost, and simple approach for the development of painless and efficient transdermal drug delivery systems.

Indexed as

electrostretchingpolymeric microneedlespulsed voltagesolvent evaporationtransdermal drug delivery

Identifiers

PMID40331415
PMCPMC12536382

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.