Evidence map›Paper›PMID 40331406›Full record

ArticleMagnetic resonance in medicine2025

A pathway toward clinical translation of hyperpolarized [1,4-

Jonathan R Birchall, Pascal Wodtke, Ashley Grimmer, Esben S S Hansen, Lotte B Bertelsen, Nikolaj Bøgh, Marta Wylot, Maria J Zamora-Morales, Otso Arponen, Ines Horvat-Menih and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Complementary hyperpolarizedNpj imaging · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Jonathan R BirchallDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0003-3920-4038
Pascal WodtkeDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-6109-4261
Ashley GrimmerDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0001-6013-5271
Esben S S HansenDepartment of Clinical Medicine, Aarhus University MR Research Centre, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-5512-9870
Lotte B BertelsenDepartment of Clinical Medicine, Aarhus University MR Research Centre, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-2491-3184
Nikolaj BøghDepartment of Clinical Medicine, Aarhus University MR Research Centre, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-0321-3269
Marta WylotDepartment of Radiology, University of Cambridge, Cambridge, UK.
Maria J Zamora-MoralesDepartment of Radiology, University of Cambridge, Cambridge, UK.
Otso ArponenDepartment of Radiology, University of Cambridge, Cambridge, UK.
Ines Horvat-MenihDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-1373-6944
Elizabeth C LatimerDepartment of Radiology, University of Cambridge, Cambridge, UK.
Fung TanRadiopharmacy Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Evita PappaDivision of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.
Johann GraggaberCambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Joseph CheriyanDivision of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.
Kelly HolmesCancer Research UK Cambridge Centre, Cambridge, UK.
Matthew J LockeDepartment of Radiology, University of Cambridge, Cambridge, UK.
Helen SladenCancer Research UK Cambridge Centre, Cambridge, UK.
Joan BorenThe Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, Cambridge, UK.
Mikko I KettunenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0002-2004-660X
Anita ChhabraRadiopharmacy Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Ian B WilkinsonDivision of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.
Christoffer LaustsenDepartment of Clinical Medicine, Aarhus University MR Research Centre, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-0317-2911
Kevin BrindleCancer Research UK Cambridge Centre, Cambridge, UK.ORCID https://orcid.org/0000-0003-3883-6287
Mary A McLeanDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-3752-0179
Ferdia A GallagherDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0003-4784-5230

Funding

Cambridge Experimental Cancer Medicine CentreCancer Research UK Cambridge Institute, University of CambridgeGates Cambridge Trust OPP1144National Cancer Imaging Translational Accelerator (NCITA)NIHR Cambridge Biomedical Research Centre BRC-1215-20014The Mark Foundation Institute for Integrative Cancer MedicineWellcome Trust
6 · The paper itself

Abstract

purposeThe detection of hyperpolarized carbon-13 (HP

methodsPreclinical biological validation was undertaken in fumarate hydratase-deficient murine tumor models and controls. Safety and biocompatibility of

resultsFumarate-to-malate conversion was reduced by 42%-71% in the knockdown murine tumor model compared to wildtype tumors. Twice-daily injection of

conclusionHP

Indexed as

FumaratesMagnetic Resonance ImagingNecrosisAdultAnimalsBiomarkersCarbon IsotopesFemaleFumarate HydrataseHumansKidneyMalatesMaleMicePhantoms, ImagingRatsBiomarkersCarbon IsotopesFumarate HydrataseFumaratesMalatesmalic acidclinical translationHP 13C‐MRIhyperpolarizationimaging biomarkernecrosispreclinical

Identifiers

PMID40331406
PMCPMC12202726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.