ArticleJournal of inflammation research2025
Mast Cells Promote Inflammatory Th17 Cells and Impair Treg Cells Through an IL-1β and PGE
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Mast Cells in the Developing Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Next-Generation regulatory T cell therapies: Translational considerations for inflammatory bowel disease.Human immunology · 2026Review
- Mast cell-derived MIF Polarizes Th17 cells to drive lung adenocarcinoma progression.Cancer immunology, immunotherapy : CII · 2026Article
- Mast cell metabolism in cancer: an underexplored frontier demanding more attention.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: CD4 Methods: This study examined human MC-Teff interactions, focusing on how MCs shape Teff responses. Flow cytometry, qRT-PCR, and cytokine assays were used to analyze the impact of primary human MCs on the Teff phenotype and function. MC-Teff crosstalk within Crohn's disease patient tissues was assessed using confocal microscopy and advanced image analysis. Results: MCs promoted the differentiation of Th17 cells, particularly the inflammatory Th17.1 subset, that secretes IFN-γ and GM-CSF. This differentiation was driven by the PGE Conclusion: MCs influence CD4
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Registered trials
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