ArticleInternational journal of women's health2025
Analysis of the Predictive Efficacy and Influencing Factors of Serum Tie-1, FoxO3a, and PKD1 for Lymph Node Metastasis in Cervical Cancer.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Systemic angiogenic protein changes following propranolol therapy in infantile hemangioma: a multi-target perspective.Frontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the factors affecting lymph node metastasis (LNM) in patients with cervical cancer and the predictive efficacy of serum tyrosine kinase receptor 1 (Tie-1), serum Forkhead Framing Protein O3a (FoxO3a), and protein kinase D1 (PKD1). Methods: Cervical cancer patients were categorized into 60 cases of LNM-positive group and 320 cases of LNM-negative group according to whether LNM occurred or not. The levels of serum Tie-1, FoxO3a and PKD1 were tested. Multivariate logistic regression analysis was conducted to identify the risk factors for cervical cancer induced lymph node metastasis (LNM). Receiver operating characteristic (ROC) curves were plotted to analyze the predictive value of various indicators for LNM in cervical cancer. Results: The percentage of patients with FIGO stage IIa, combined paracervical infiltration and myometrial infiltration was significantly higher in the LNM-positive group than in the LNM-negative group (P<0.05). Huanz serum levels of Tie-1 and PKD1 in the LNM-positive group were significantly higher than those in the LNM-negative group, and the relative expression of FoxO3a was significantly lower than that in the LNM-negative group (P<0.05). The results of logistic regression analysis showed that FIGO stage, parietal infiltration, myometrial infiltration, serum Tie-1, PKD1 were LNM-positive in cervical cancer patients (P<0.05), and low level of relative expression of serum FoxO3a was a protective factor (P<0.05). The cutoff of serum Tie-1, FoxO3a, and PKD1 levels for predicting the occurrence of LNM in cervical cancer were 1.97 ng/mL, 0.54, and 113.26 μg/L, and the area under the ROC curve (AUC) was 0.852, 0.827, 0.844, respectively. Conclusion: Serum Tie-1, FoxO3a and PKD1 have certain predictive efficacy for lymph node metastasis, and the combination of these tests can improve the predictive accuracy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.