ArticleFrontiers in nutrition2025
The impact of serum uric acid on biological aging and mortality risk: insights from the NHANES and CHARLS cohorts.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association Between Iron Availability and Accelerated Biological Aging in Non-Anemic Women of Reproductive Age: A Nationally Representative Cross-Sectional Study.Biological trace element research · 2026Article
- Continence Impairment and Depressive Symptoms Jointly Identify Older Adults at Increased Risk of Mortality: Parallel Analyses From NHANES and CHARLS.Geriatrics & gerontology international · 2026Article
- Associations of Social Determinants of Health Scores with Visual Impairment and Premature Death in Visually Impaired Adults: Insights from CHARLS-A Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Association of the C-reactive protein-triglyceride-glucose index with metabolic dysfunction-associated steatotic liver disease and long-term all-cause and cardiovascular mortality: evidence from two nationwide prospective cohort studies.Cardiovascular diabetology · 2026Article
- Differential associations of febuxostat and allopurinol with incident and worsening frailty risk in nephrology patients.International journal of medical sciences · 2026Article
- Evaluating the Oxidative Balance Score for Peripheral Artery Disease Risk: Integrating Epidemiologic Modeling and SHAP-Interpretable Machine Learning in NHANES.Food science & nutrition · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Serum uric acid (SUA), a byproduct of purine metabolism, exerts both antioxidant and pro-inflammatory effects, making its role in aging and chronic diseases a subject of ongoing debate. Despite this, the mechanisms by which SUA influences the aging process remain poorly understood. Methods: We analyzed data from the NHANES (1999-2010) and CHARLS (2011-2015) cohorts to investigate SUA's impact on biological aging. Generalized linear regression models assessed SUA's effect on biological aging markers [ΔKDM-BA, ΔPhenoAge, and allostatic load (AL)], while Cox regression models estimated its association with all-cause and premature mortality. Dose-response relationships between SUA levels and aging markers (ΔKDM-BA, ΔPhenoAge, and AL), as well as all-cause and premature mortality, were evaluated using restricted cubic splines (RCS). Results: In both cohorts, elevated SUA levels were significantly associated with accelerated aging. In the NHANES cohort, for each 1 mg/dL increase in SUA, ΔKDM-BA increased by 0.52 years (95% CI: 0.43-0.61, Conclusion: Elevated SUA is associated with accelerated biological aging in both U.S. and Chinese populations, but its link to mortality was evident only in the NHANES cohort. These findings highlight SUA as a potential aging marker and call for further population-specific investigation.
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